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3/16/2023 1:25:39 AM | Browse: 358 | Download: 1541
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Received |
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2022-09-22 07:50 |
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Peer-Review Started |
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2022-09-22 07:54 |
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First Decision by Editorial Office Director |
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2022-12-26 08:27 |
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2022-12-26 08:27 |
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Revised |
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2023-01-08 13:36 |
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Second Decision by Editor |
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2023-02-15 03:52 |
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Final Decision by Editorial Office Director |
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2023-02-15 21:07 |
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Articles in Press |
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2023-02-15 21:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-09 11:06 |
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Publish the Manuscript Online |
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2023-03-15 15:41 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Nε-(carboxymethyl)lysine promotes lipid uptake of macrophage via cluster of differentiation 36 and receptor for advanced glycation end products
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Qun Wang, Hai-Peng Yao and Zhen Sun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82070455 |
| Natural Science Foundation of Jiangsu Province |
BK20201225 |
| Medical Innovation Team Project of Jiangsu Province |
CXTDA2017010 |
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| Corresponding Author |
Zhen Sun, PhD, Doctor, Doctor, Department of Cardiology, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, China. 1398041019@qq.com |
| Key Words |
Nε-(carboxymethyl)lysine; Cluster of differentiation 36; Receptor for advanced glycation end products; Lipid uptake; Macrophage |
| Core Tip |
Nε-(carboxymethyl)lysine (CML), a toxic metabolism product in diabetes mellites, is a causative factor of many diseases. CML has been reported to promote lipid uptake in macrophages and foam cell formation. The receptor for advanced glycation end products (RAGE) and cluster of differentiation 36 (CD36) are receptors of CML. However, the roles of RAGE and CD36 in CML-induced lipid uptake in macrophages are currently unclear. Moreover, the relationship and difference between RAGE and CD36 in this process are also worth exploring. The in vitro model was constructed with Raw264.7 cells. Under the stimulation of CML, the lipid uptake by cells was significantly increased. Inhibition of CD36 or RAGE antagonized CML-induced lipid uptake. We synthesized a probe of 18F-CML to explore the relationship of CML to CD36 and to RAGE. CML could bind to CD36 and to RAGE, and CML has a significantly stronger affinity for CD36 than for RAGE. The exploration of the pathogenic mechanism of CML may provide evidence for a deeper understanding of diseases related to metabolic disorders. |
| Publish Date |
2023-03-15 15:41 |
| Citation |
Wang ZQ, Yao HP, Sun Z. Nε-(carboxymethyl)lysine promotes lipid uptake of macrophage via cluster of differentiation 36 and receptor for advanced glycation end products. World J Diabetes 2024; In press
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| URL |
https://www.wjgnet.com/1948-9358/full/v14/i3/222.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i3.222 |
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