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2/6/2023 12:41:18 PM | Browse: 119 | Download: 425
Publication Name World Journal of Gastroenterology
Manuscript ID 80399
Country/Territory Japan
Received
2022-11-04 06:59
Peer-Review Started
2022-10-29 04:44
To Make the First Decision
Return for Revision
2022-11-30 07:58
Revised
2022-12-07 10:16
Second Decision
2023-01-12 03:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-01-12 19:20
Articles in Press
2023-01-12 19:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-01-28 10:54
Publish the Manuscript Online
2023-02-06 12:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Impact of endothelial nitric oxide synthase activation on accelerated liver regeneration in a rat ALPPS model
Manuscript Source Unsolicited Manuscript
All Author List Hitoshi Masuo, Akira Shimizu, Hiroaki Motoyama, Koji Kubota, Tsuyoshi Notake, Takahiro Yoshizawa, Kiyotaka Hosoda, Koya Yasukawa, Akira Kobayashi and Yuji Soejima
Funding Agency and Grant Number
Funding Agency Grant Number
JSPS KAKENHI JP17K10664
Corresponding Author Akira Shimizu, MD, PhD, Associate Professor, Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto 390-8621, Japan. ashimizu@shinshu-u.ac.jp
Key Words Hepatectomy; Nitric oxide; Liver regeneration; Cytokines; NG-Nitroarginine methyl ester; Molsidomine
Core Tip In extended hepatectomy for hepatobiliary tumors, adequate future liver remnant (FLR) is essential to prevent postoperative liver failure. Portal vein embolization (PVE) and associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) are performed to increase the FLR. Although ALPPS induces more rapid liver regeneration than PVE, the mechanism remains unclear. In this study, we compared ALPPS with portal vein ligation (PVL) in a rat model and found that activation of the Akt-endothelial nitric oxide synthase pathway promotes liver regeneration. The combination of PVL and nitric oxide-producing agents may induce liver regeneration comparable to ALPPS in a non-invasive manner.
Publish Date 2023-02-06 12:22
Citation Masuo H, Shimizu A, Motoyama H, Kubota K, Notake T, Yoshizawa T, Hosoda K, Yasukawa K, Kobayashi A, Soejima Y. Impact of endothelial nitric oxide synthase activation on accelerated liver regeneration in a rat ALPPS model. World J Gastroenterol 2023; 29(5): 867-878
URL https://www.wjgnet.com/1007-9327/full/v29/i5/867.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i5.867
Full Article (PDF) WJG-29-867.pdf
Full Article (Word) WJG-29-867.docx
Manuscript File 80399_Auto_Edited-LM.docx
Answering Reviewers 80399-Answering reviewers.pdf
Audio Core Tip 80399-Audio core tip.mp3
Biostatistics Review Certificate 80399-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 80399-Conflict-of-interest statement.pdf
Copyright License Agreement 80399-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 80399-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 80399-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 80399-Language certificate.pdf
Peer-review Report 80399-Peer-review(s).pdf
Scientific Misconduct Check 80399-Bing-Wang JJ-2.png
Scientific Editor Work List 80399-Scientific editor work list.pdf