Publication Name	World Journal of Biological Chemistry
Manuscript ID	8042
Country	United States

Received	2013-12-12 16:53
Peer-Review Started	2013-12-13 08:14
To Make the First Decision	2014-04-28 14:27
Return for Revision	2014-05-06 10:06
Revised	2014-05-20 04:35
Second Decision	2014-09-10 09:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-10 09:39
Articles in Press	2014-09-10 09:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 09:11
Publish the Manuscript Online	2014-12-02 12:16

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation
Manuscript Source	Invited Manuscript
All Author List	Hironori Adachi and Yi-Tao Yu
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Health to Yi-Tao Yu GM104077 National Institute of Health to Yi-Tao Yu AG39559 University of Rochester CTSA award from the National Center for Advancing Translational Sciences of the National Institute of Health UL1TR000042 (to Yi-Tao Yu)
Corresponding Author	Yi-Tao Yu, PhD, Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, United States. yi-tao_yu@urmc.rochester.edu
Key Words	Pre-mRNA splicing; U2 snRNA; Box H/ACA ribonucleoprotein; Pseudouridine; Induced RNA modification
Core Tip	Pseudouridines (Ψs) are the most abundant and highly conserved modified nucleotides identified in various stable RNAs of all organisms. Most Ψs are clustered in regions that are functionally important for pre-mRNA splicing. Ψ has an extra hydrogen bond donor that endows RNA molecules with distinct properties that contribute significantly to RNA-mediated cellular processes. Experimental data indicate that spliceosomal snRNA pseudouridylation can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Recent work has also demonstrated that pseudouridylation can be induced at novel positions under stress conditions, suggesting a regulatory role for Ψ.
Publish Date	2014-12-02 12:16
Citation	Adachi H, Yu YT. Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation. World J Biol Chem 2014; 5(4): 398-408
URL	http://www.wjgnet.com/1949-8454/full/v5/i4/398.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i4.398

Full Article (PDF)	WJBC-5-398.pdf
Full Article (Word)	WJBC-5-398.doc
Manuscript File	8042-Review.docx
Answering Reviewers	8042-Answering reviewers.pdf
Copyright License Agreement	8042-Copyright assignment.pdf
Peer-review Report	8042-Peer review(s).pdf
Scientific Misconduct Check	8042-CrossCheck.jpg
Scientific Editor Work List	8042-Scientific editor work list.pdf