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4/24/2023 12:33:16 PM | Browse: 197 | Download: 715
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Received |
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2022-10-19 05:55 |
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Peer-Review Started |
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2022-10-19 05:58 |
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To Make the First Decision |
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Return for Revision |
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2022-12-12 07:57 |
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Revised |
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2022-12-17 07:08 |
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Second Decision |
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2023-04-07 06:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-04-07 07:36 |
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Articles in Press |
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2023-04-07 07:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-01-09 03:56 |
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Typeset the Manuscript |
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2023-04-15 09:00 |
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Publish the Manuscript Online |
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2023-04-24 11:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Future therapeutic implications of new molecular mechanism of colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sen Lu, Cheng-You Jia and Jian-She Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
72171170, 82071964 |
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| Corresponding Author |
Jian-She Yang, MD, MM, MSc, PhD, Academic Editor, Academic Fellow, Academic Research, Full Professor, Professor, Department of Nuclear Medicine and Oncology Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Yanchang Road (Middle), Shanghai 200072, China. yangjs@impcas.ac.cn |
| Key Words |
Colorectal cancer; Laterally spreading tumors; Molecular mechanism; Truncated adenomatous polyposis coli mutation; Golgi fragmentation; Cancerous mechanism |
| Core Tip |
Although laterally spreading tumors (LST) are considered vital precancerous lesions of colorectal cancer (CRC), the mechanism mediating their transition to CRC development is unclear. Adenomatous polyposis coli (APC)-truncating mutations driven by Golgi fragmentation are very important cellular events that can abrogate the microtubule binding properties of APC. This effect reduces the stability of microtubules, impacts cell proliferation and survival, causes chromosomal instability, and increases migration. Downstream characteristics of Golgi fragmentation indicate alterations in Ataxia-telangiectasia mutated and anoctamin 5 expression, whereas their gene expression changes are significant in LST. This implies a novel pathway for CRC development from LST. |
| Publish Date |
2023-04-24 11:14 |
| Citation |
Lu S, Jia CY, Yang JS. Future therapeutic implications of new molecular mechanism of colorectal cancer. World J Gastroenterol 2023; 29(16): 2359-2368 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i16/2359.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i16.2359 |
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