Publication Name	World Journal of Hepatology
Manuscript ID	80986
Country	China

Received	2022-10-28 02:52
Peer-Review Started	2022-10-28 02:54
To Make the First Decision
Return for Revision	2023-01-04 14:37
Revised	2023-01-14 15:01
Second Decision	2023-03-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-03-17 07:30
Articles in Press	2023-03-17 07:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-03-20 00:12
Publish the Manuscript Online	2023-03-22 11:20

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	COVID-19 and liver dysfunction in children: Current views and new hypotheses
Manuscript Source	Invited Manuscript
All Author List	Yang-Fang Yun, Zhi-Yuan Feng and Jing-Jing Zhang
Funding Agency and Grant Number
Corresponding Author	Jing-Jing Zhang, Doctor, Professor, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University, No. 163 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. jing15209791@nju.edu.cn
Key Words	COVID-19; SARS-CoV-2; Children; Liver injury; Inflammatory immune response; Cytokine storm
Core Tip	There are few cases of liver injury in children with Coronavirus disease 2019 (COVID-19) and clinical reports are scarce. We collected reports on COVID-19-related liver injury (CRLI) in children over the last two years and divided the etiology of CRLI into three categories: (1) the direct mechanism involves severe acute respiratory syndrome coronavirus 2 binding to angiotensin-converting enzyme 2 in the liver or bile duct to exert direct toxicity; (2) the indirect mechanisms include an inflammatory immune response and hypoxia; and (3) COVID-19-related treatments, such as mechanical ventilation and antiviral drugs, may cause liver injury. We also discuss the current controversies regarding the pathophysiology of CRLI.
Publish Date	2023-03-22 11:20
Citation	Yun YF, Feng ZY, Zhang JJ. COVID-19 and liver dysfunction in children: Current views and new hypotheses. World J Hepatol 2023; 15(3): 353-363
URL	https://www.wjgnet.com/1948-5182/full/v15/i3/353.htm
DOI	https://dx.doi.org/10.4254/wjh.v15.i3.353

Full Article (PDF)	WJH-15-353-with-cover.pdf
Full Article (Word)	WJH-15-353.docx
Manuscript File	80986_Auto_Edited-JLW.docx
Answering Reviewers	80986-Answering reviewers.pdf
Audio Core Tip	80986-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80986-Conflict-of-interest statement.pdf
Copyright License Agreement	80986-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	80986-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	80986-Language certificate.pdf
Peer-review Report	80986-Peer-review(s).pdf
Scientific Misconduct Check	80986-Bing-Chang KL-2.png
Scientific Editor Work List	80986-Scientific editor work list.pdf
CrossCheck Report	80986-CrossCheck report.pdf