Publication Name	World Journal of Hepatology
Manuscript ID	81070
Country	United Kingdom

Received	2022-10-26 13:56
Peer-Review Started	2022-10-27 14:39
To Make the First Decision
Return for Revision	2022-11-16 14:41
Revised	2022-11-22 15:41
Second Decision	2023-02-15 03:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-02-15 07:57
Articles in Press	2023-02-15 07:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-16 02:57
Publish the Manuscript Online	2023-02-24 13:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Bioengineering liver tissue by repopulation of decellularised scaffolds
Manuscript Source	Invited Manuscript
All Author List	Zeeshan Afzal and Emmanuel Laurent Huguet
Funding Agency and Grant Number
Corresponding Author	Emmanuel Laurent Huguet, BSc, FRCS (Ed), PhD, Researcher, Surgeon, Surgical Oncologist, Department of Surgery, Addenbrookes Hospital, NIHR Comprehensive Biomedical Research and Academic Health Sciences Centre. Cambridge University Hospitals NHS Foundation Trust., Hills Road, Cambridge CB2 0QQ, United Kingdom. eh516@cam.ac.uk
Key Words	Regenerative; Bioengineering; Scaffolds; Liver; Decellularisation; Recellularisation
Core Tip	Given the limited resource of livers for transplantation, repopulation of decellularised scaffolds with recipient cells offers a theoretically attractive organ source without the need for immunosuppression. Bioengineered livers have progressed from small rodent to large animal blood perfusion models. Although some hepatocyte function has been achieved, challenges remain in cholangiocyte repopulation, reconstitution of the vasculature, and other minority cell groups. The cell types used in experimental models to date have yielded advances but may need to be altered if the currently distant prospect of clinical application is to be envisaged.
Publish Date	2023-02-24 13:35
Citation	Afzal Z, Huguet EL. Bioengineering liver tissue by repopulation of decellularised scaffolds. World J Hepatol 2023; 15(2): 151-179
URL	https://www.wjgnet.com/1948-5182/full/v15/i2/151.htm
DOI	https://dx.doi.org/10.4254/wjh.v15.i2.151

Full Article (PDF)	WJH-15-151.pdf
Full Article (Word)	WJH-15-151.docx
Manuscript File	81070_Auto_Edited-JLW.docx
Answering Reviewers	81070-Answering reviewers.pdf
Audio Core Tip	81070-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	81070-Conflict-of-interest statement.pdf
Copyright License Agreement	81070-Copyright license agreement.pdf
Peer-review Report	81070-Peer-review(s).pdf
Scientific Editor Work List	81070-Scientific editor work list.pdf
CrossCheck Report	81070-CrossCheck report.pdf