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5/24/2023 10:28:01 AM | Browse: 184 | Download: 686
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Received |
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2022-11-19 01:49 |
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Peer-Review Started |
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2022-11-19 13:08 |
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To Make the First Decision |
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Return for Revision |
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2023-02-02 17:12 |
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Revised |
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2023-03-13 23:16 |
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Second Decision |
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2023-04-11 03:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-04-12 03:04 |
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Articles in Press |
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2023-04-12 03:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-04-10 23:55 |
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Typeset the Manuscript |
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2023-05-17 07:50 |
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Publish the Manuscript Online |
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2023-05-24 09:31 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
Copyright: © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Current and novel modalities for management of chronic hepatitis B infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Iman Ibrahim Salama, Samia M Sami, Somaia I Salama, Ghada A Abdel-Latif, Fatma A Shaaban, Walaa A Fouad, Aida M Abdelmohsen and Hala M Raslan |
| Funding Agency and Grant Number |
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| Corresponding Author |
Iman Ibrahim Salama, MD, Academic Research, Research Scientist, Department of Community Medicine Research, National Research Center, El bouhoth street, Giza 12411, Dokki, Egypt. salamaiman@yahoo.com |
| Key Words |
Current modalities; Novel modalities; Management; Chronic hepatitis B infection; Direct acting antiviral therapy; Immunotherapy; Therapeutic vaccination |
| Core Tip |
Chronic hepatitis B virus (HBV) infection is a result of immune tolerance and the presence of covalently closed circular DNA and the integrated HBV. The currently approved therapies are nucleos(t)ide analogues, interferon-alpha, and pegylated-interferon-alpha, with functional cure achieved in < 10% of patients. Disruption of the interaction between HBV or the host immune system can lead to HBV reactivation. Novel therapies include direct acting antivirals and immunomodulators. Immunomodulators may enhance/restore innate and adaptive immunity against HBV (as toll-like-receptors and retinoic acid inducible gene-1 agonist), checkpoint inhibitors, therapeutic HBV vaccines, and genetically engineered T cells to restore T cell function. |
| Publish Date |
2023-05-24 09:31 |
| Citation |
Salama II, Sami SM, Salama SI, Abdel-Latif GA, Shaaban FA, Fouad WA, Abdelmohsen AM, Raslan HM. Current and novel modalities for management of chronic hepatitis B infection. World J Hepatol 2023; 15(5): 585-608 |
| URL |
https://www.wjgnet.com/1948-5182/full/v15/i5/585.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v15.i5.585 |
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