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5/24/2023 10:28:01 AM | Browse: 22 | Download: 28
Publication Name World Journal of Hepatology
Manuscript ID 81652
Country/Territory Egypt
2022-11-19 01:49
Peer-Review Started
2022-11-19 13:08
To Make the First Decision
Return for Revision
2023-02-02 17:12
2023-03-13 23:16
Second Decision
2023-04-11 03:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-04-12 03:04
Articles in Press
2023-04-12 03:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2023-04-10 23:55
Typeset the Manuscript
2023-05-17 07:50
Publish the Manuscript Online
2023-05-24 09:31
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright Copyright: © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Current and novel modalities for management of chronic hepatitis B infection
Manuscript Source Invited Manuscript
All Author List Iman Ibrahim Salama, Samia M Sami, Somaia I Salama, Ghada A Abdel-Latif, Fatma A Shaaban, Walaa A Fouad, Aida M Abdelmohsen and Hala M Raslan
Funding Agency and Grant Number
Corresponding Author Iman Ibrahim Salama, MD, Academic Research, Research Scientist, Department of Community Medicine Research, National Research Center, El bouhoth street, Giza 12411, Dokki, Egypt. salamaiman@yahoo.com
Key Words Current modalities; Novel modalities; Management; Chronic hepatitis B infection; Direct acting antiviral therapy; Immunotherapy; Therapeutic vaccination
Core Tip Chronic hepatitis B virus (HBV) infection is a result of immune tolerance and the presence of covalently closed circular DNA and the integrated HBV. The currently approved therapies are nucleos(t)ide analogues, interferon-alpha, and pegylated-interferon-alpha, with functional cure achieved in < 10% of patients. Disruption of the interaction between HBV or the host immune system can lead to HBV reactivation. Novel therapies include direct acting antivirals and immunomodulators. Immunomodulators may enhance/restore innate and adaptive immunity against HBV (as toll-like-receptors and retinoic acid inducible gene-1 agonist), checkpoint inhibitors, therapeutic HBV vaccines, and genetically engineered T cells to restore T cell function.
Publish Date 2023-05-24 09:31
Citation Salama II, Sami SM, Salama SI, Abdel-Latif GA, Shaaban FA, Fouad WA, Abdelmohsen AM, Raslan HM. Current and novel modalities for management of chronic hepatitis B infection. World J Hepatol 2023; 15(5): 585-608
URL https://www.wjgnet.com/1948-5182/full/v15/i5/585.htm
DOI https://dx.doi.org/10.4254/wjh.v15.i5.585
Full Article (PDF) WJH-15-585.pdf
Full Article (Word) WJH-15-585.docx
Manuscript File 81652_Auto_Edited-XFL-Filipodia-JLW.docx
Answering Reviewers 81652-Answering reviewers.pdf
Audio Core Tip 81652-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 81652-Conflict-of-Interest-Disclosure-Form-revision.pdf
Copyright License Agreement 81652-Copyright-License-Agreement-revision.pdf
Non-Native Speakers of English Editing Certificate 81652-Language certificate.pdf
Peer-review Report 81652-Peer-review(s).pdf
Scientific Misconduct Check 81652-Bing-Liu XF-2.png
Scientific Editor Work List 81652-Scientific editor work list.pdf