Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	81757
Country	China

Received	2022-12-02 11:41
Peer-Review Started	2022-12-02 11:43
To Make the First Decision
Return for Revision	2023-01-16 06:58
Revised	2023-01-26 06:32
Second Decision	2023-04-04 03:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-04-04 08:15
Articles in Press	2023-04-04 08:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-05 04:50
Publish the Manuscript Online	2023-05-12 09:13

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Intratumour microbiome of pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Shi-Wei Guan, Quan Lin and Hai-Bo Yu
Funding Agency and Grant Number
Corresponding Author	Hai-Bo Yu, MD, Chief Doctor, Department of Surgery, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, No. 252 Baili East Road, Wenzhou 325000, Zhejiang Province, China. yuhaibozjwz@163.com
Key Words	Intratumour microbiome; Pancreatic cancer; Tumour microenvironment; Chemoresistance; Diagnosis; Prognosis
Core Tip	Recently, with the development of high-throughput sequencing, tumour tissues, which were previously believed to be sterile, have been shown to harbor a low microbiome biomass. The intratumour microbiome is crucial for pancreatic ductal adenocarcinoma (PDAC) diagnosis, treatment, chemotherapy resistance, and immune response. Establishing an awareness of the biology of the tumour microbiome in PDAC supports the establishment of better strategies for PDAC. This review focuses on the possible origins of the microbiome, the localization, the interaction with the tumour microenvironment and the strategies for improving the outcomes of treatment. This review offers new perspectives for improving the prognosis of PDAC.
Publish Date	2023-05-12 09:13
Citation	Guan SW, Lin Q, Yu HB. Intratumour microbiome of pancreatic cancer. World J Gastrointest Oncol 2023; 15(5): 713-730
URL	https://www.wjgnet.com/1948-5204/full/v15/i5/713.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i5.713

Full Article (PDF)	WJGO-15-713.pdf
Full Article (Word)	WJGO-15-713.docx
Manuscript File	81757_Auto_Edited-JLW.doc
Answering Reviewers	81757-Answering reviewers.pdf
Audio Core Tip	81757-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	81757-Conflict-of-interest statement.pdf
Copyright License Agreement	81757-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	81757-Language certificate.pdf
Peer-review Report	81757-Peer-review(s).pdf
Scientific Misconduct Check	81757-Bing-Fan JR-2.png
Scientific Editor Work List	81757-Scientific editor work list.pdf