| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liu Shi, Li Zhou, Ming Han, Yu Zhang, Yang Zhang, Xiao-Xue Yuan, Hong-Ping Lu, Yun Wang, Xue-Liang Yang, Chen Liu, Jun Wang, Pu Liang, Shun-Ai Liu, Xiao-Jing Liu, Jun Cheng and Shu-Mei Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2017YFC0908104 |
| National Science and Technology Projects |
2017ZX10203201, 2017ZX10201201, 2017ZX10202202 |
|
| Corresponding Author |
Shu-Mei Lin, Doctor, MD, PhD, Doctor, Doctor, Professor, Teacher, Department of Infectious Disease Medicine, The First Hospital Affiliated to Xi’an Jiaotong University, No. 277 Yanta West Road, Yanta, Xi’an 710061, Shaanxi Province, China. lsmxjtu@126.com |
| Key Words |
Nonstructural protein 3-transactivated protein 1; Calcitriol; Liver fibrosis; Hepatic stellate cells; Mouse model; TGFβ1/Smad3; NF-κB; Signaling pathway |
| Core Tip |
We proved that hepatitis C virus nonstructural protein 3-transactivated protein 1 (NS3TP1) promoted hepatic fibrosis via the transforming growth factor beta 1/Smad3 and NF-κB signaling pathways. Calcitriol attenuates liver fibrosis through NS3TP1-mediated above both signaling pathways. These novel findings profoundly expand our knowledge about the mechanisms underlying the role and function of NS3TP1 in hepatic fibrosis. The relationship between NS3TP1 and liver fibrosis was discussed for the first time and provided a foundation for research related to liver fibrosis by targeting NS3TP1. We first showed that calcitriol alleviated hepatic fibrosis through the above signaling pathways via NS3TP1. |
| Publish Date |
2023-05-11 08:05 |
| Citation |
Shi L, Zhou L, Han M, Zhang Y, Zhang Y, Yuan XX, Lu HP, Wang Y, Yang XL, Liu C, Wang J, Liang P, Liu SA, Liu XJ, Cheng J, Lin SM. Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways. World J Gastroenterol 2023; 29(18): 2798-2817 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i18/2798.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i18.2798 |
