| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Network-pharmacology-based research on effects of Shuxin decoction and mechanism underlying its protection against myocardial ischemia/reperfusion injury with diabetes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling Yang, Yang Jian, Zai-Yuan Zhang, Bao-Wen Qi, Yu-Bo Li, Pan Long, Yao Yang, Xue Wang, Shuo Huang, Jing Huang, Long-Fu Zhou, Jie Ma, Chang-Qing Jiang, Yong-He Hu and Wen-Jing Xiao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Sichuan Province |
2022NSFSC0738 |
| Basic Research Funds for Central Universities |
2682022ZTPY038 |
| Tibet Autonomous Region Science and Technology Planning Project |
XZ2022RH001 |
|
| Corresponding Author |
Wen-Jing Xiao, Department of Pharmacy, The General Hospital of Western Theater Command, No.270 Tianhui Road, Chengdu 610083, Sichuan Province, China. xwj-4321@163.com |
| Key Words |
Chinese herbal drugs; Network-pharmacology; Diabetes; Myocardial reperfusion injury; Shuxin decoction |
| Core Tip |
Patients with diabetes are susceptible to myocardial ischemia/reperfusion injury (MI/RI). The efficacy of implementing strict glycemic control to reduce cardiovascular mortality in patients with diabetes has not been established to yield significant benefits. Here, we evaluated a recipe [Shuxin decoction (SXT)], which was modified from the classic herbal formula "Wu-tou-chi-shi-zhi-wan" in traditional Chinese medicine. Animal experiments based on findings from network-pharmacology indicated that SXT could regulate lipid metabolism, alleviate cardiomyocyte apoptosis, and attenuate MI/RI in diabetes through the advanced glycation endproducts (AGE)-receptor for AGE signaling pathway. These findings could potentially facilitate developing novel complementary or alternative form of medicine for effectively managing MI/RI with diabetes. |
| Publish Date |
2023-07-13 08:03 |
| Citation |
Yang L, Jian Y, Zhang ZY, Qi BW, Li YB, Long P, Yang Y, Wang X, Huang S, Huang J, Zhou LF, Ma J, Jiang CQ, Hu YH, Xiao WJ. Network-pharmacology-based research on effects of Shuxin decoction and mechanism underlying its protection against myocardial ischemia/reperfusion injury with diabetes. World J Diabetes 2023; 14(7): 1057-1076 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i7/1057.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i7.1057 |
