Publication Name	World Journal of Gastroenterology
Manuscript ID	83422
Country	Italy

Received	2023-01-23 21:45
Peer-Review Started	2023-01-23 21:51
To Make the First Decision
Return for Revision	2023-02-07 19:50
Revised	2023-02-28 16:19
Second Decision	2023-04-17 05:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-17 08:09
Articles in Press	2023-04-17 08:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-05 06:42
Publish the Manuscript Online	2023-05-11 08:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Wingless/It/β-catenin signaling in liver metastasis from colorectal cancer: A focus on biological mechanisms and therapeutic opportunities
Manuscript Source	Invited Manuscript
All Author List	Federico Selvaggi, Teresa Catalano, Rossano Lattanzio, Roberto Cotellese and Gitana Maria Aceto
Funding Agency and Grant Number
Corresponding Author	Gitana Maria Aceto, MSc, PhD, Research Scientist, Senior Lecturer, Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini, Chieti 66100, Italy. gitana.aceto@unich.it
Key Words	Wingless/It/β-catenin signaling; Colorectal cancer; Epithelial-mesenchymal transition/mesenchymal-epithelial transition; Liver metastasis; Markers; Surgical and non-surgical therapies
Core Tip	The liver is the most common site of metastasis in patients with colorectal cancer. Wingless/It (Wnt)/β-catenin signals can drive progression and metastatization by epithelial-mesenchymal transition/mesenchymal-epithelial transition. In the hepatic microenvironment, metastatic cells can survive through dormancy and become refractory to therapy. Further studies are needed to elucidate involvement of Wnt signaling in the development of colorectal liver metastases and to improve current surgical and non-surgical therapeutic approaches.
Publish Date	2023-05-11 08:05
Citation	Selvaggi F, Catalano T, Lattanzio R, Cotellese R, Aceto GM. Wingless/It/β-catenin signaling in liver metastasis from colorectal cancer: A focus on biological mechanisms and therapeutic opportunities. World J Gastroenterol 2023; 29(18): 2764-2783
URL	https://www.wjgnet.com/1007-9327/full/v29/i18/2764.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i18.2764

Full Article (PDF)	WJG-29-2764.pdf
Full Article (Word)	WJG-29-2764.docx
Manuscript File	83422_Auto_Edited-JLW.docx
Answering Reviewers	83422-Answering reviewers.pdf
Audio Core Tip	83422-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	83422-Conflict-of-interest statement.pdf
Copyright License Agreement	83422-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	83422-Language certificate.pdf
Peer-review Report	83422-Peer-review(s).pdf
Scientific Misconduct Check	83422-Bing-Wang JJ-2.png
Scientific Editor Work List	83422-Scientific editor work list.pdf
CrossCheck Report	83422-CrossCheck report.pdf