Publication Name	World Journal of Gastroenterology
Manuscript ID	83450
Country	United Kingdom

Received	2023-01-25 15:50
Peer-Review Started	2023-01-25 15:54
To Make the First Decision
Return for Revision	2023-03-15 03:41
Revised	2023-03-23 10:34
Second Decision	2023-05-04 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-05-04 23:19
Articles in Press	2023-05-04 23:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-05-08 20:54
Typeset the Manuscript	2023-05-25 06:11
Publish the Manuscript Online	2023-06-07 06:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	Overview of current detection methods and microRNA potential in Clostridium difficile infection screening
Manuscript Source	Invited Manuscript
All Author List	Marco Bocchetti, Maria Grazia Ferraro, Federica Melisi, Piera Grisolia, Marianna Scrima, Alessia Maria Cossu and Tung On Yau
Funding Agency and Grant Number
Corresponding Author	Tung On Yau, BSc, MSc, PhD, Instructor, Lecturer, Researcher, School of Science and Technology, Nottingham Trent University, Clifton Lane, Clifton, Nottingham NG11 8NS, United Kingdom. payton.yau@ntu.ac.uk
Key Words	Clostridioides difficile; microRNA; Diagnostic; Prognostic; Biomarker
Core Tip	Clostridioides difficile (C. difficile) infection (CDI) is listed as an urgent threat and early detection and appropriate disease management from hospital-acquired or community-acquired CDI appear to be essential. Currently, stool-based non-invasive screening is the first-line approach to CDI diagnosis, but the accuracy is varied due to different clinical microbiology detection methods; therefore, improving reliability is clearly required. This review summarizes the life cycle and toxicity of C. difficile and examines existing diagnostic potentials on microRNA as novel biomarkers. miRNAs can be easily detected through non-invasive liquid biopsy and can also yield crucial information about ongoing pathological phenomena, particularly in CDI.
Publish Date	2023-06-07 06:39
Citation	Bocchetti M, Ferraro MG, Melisi F, Grisolia P, Scrima M, Cossu AM, Yau TO. Overview of current detection methods and microRNA potential in Clostridium difficile infection screening. World J Gastroenterol 2023; 29(22): 3385-3399
URL	https://www.wjgnet.com/1007-9327/full/v29/i22/3385.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i22.3385

Full Article (PDF)	WJG-29-3385-with-cover.pdf
Full Article (Word)	WJG-29-3385.docx
Manuscript File	83450-Review-FilipodiaCL.docx
Answering Reviewers	83450-Answering reviewers.pdf
Audio Core Tip	83450-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	83450-Conflict-of-interest statement.pdf
Copyright License Agreement	83450-Copyright license agreement.pdf
Supplementary Material	83450-Supplementary material.pdf
Peer-review Report	83450-Peer-review(s).pdf
Scientific Misconduct Check	83450-Bing-Fan JR-2.png
Scientific Editor Work List	83450-Scientific editor work list.pdf