Publication Name	World Journal of Medical Genetics
Manuscript ID	83776
Country	United States

Received	2023-02-08 19:16
Peer-Review Started	2023-02-08 19:18
To Make the First Decision
Return for Revision	2023-04-28 07:55
Revised	2023-04-28 19:13
Second Decision	2023-05-22 03:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-05-22 09:11
Articles in Press	2023-05-22 09:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-30 09:27
Publish the Manuscript Online	2023-06-02 07:10

ISSN	2220-3184 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Genetics & Heredity
Manuscript Type	Basic Study
Article Title	Genome-wide associations, polygenic risk, and Mendelian randomization reveal limited interactions between John Henryism and cynicism
Manuscript Source	Unsolicited Manuscript
All Author List	Richard R Chapleau
Funding Agency and Grant Number
Corresponding Author	Richard R Chapleau, PhD, Senior Scientist, Department of Genetics, NeuroStat Analytical Solutions, 1142 Walker Rd, Suite H, Great Falls, VA 22066, United States. richard.chapleau@nsas-llc.com
Key Words	Cynicism; Burnout syndrome; John Henryism; Genome-wide association study; Polygenic risk score; Machine-learning
Core Tip	This study evaluates the interaction of a job-related cardiovascular disease risk factor (John Henryism) and the development of occupational burnout (specifically the cynicism and cynical distrust components). Genome-wide associations and statistical genetics revealed that while John Henryism is not a risk factor for burnout syndrome, there are independent genetic risk factors for both John Henryism and cynicism. These new results provide additional tools to industrial and occupational psychologists, as well as cardiologists, to help reduce burnout incidence.
Publish Date	2023-06-02 07:10
Citation	Chapleau RR. Genome-wide associations, polygenic risk, and Mendelian randomization reveal limited interactions between John Henryism and cynicism. World J Med Genet 2023; 11(2): 8-20
URL	https://www.wjgnet.com/2220-3184/full/v11/i2/8.htm
DOI	https://dx.doi.org/10.5496/wjmg.v11.i2.8

Full Article (PDF)	WJMG-11-8.pdf
Full Article (Word)	WJMG-11-8.docx
Manuscript File	83776_Auto_Edited-LJH-JLW.docx
Answering Reviewers	83776-Answering reviewers.pdf
Audio Core Tip	83776-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	83776-Conflict-of-interest statement.pdf
Copyright License Agreement	83776-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	83776-Institutional review board statement.pdf
Peer-review Report	83776-Peer-review(s).pdf
Scientific Misconduct Check	83776-Bing-Liu JH-2.png
Scientific Misconduct Check	83776-CrossCheck.png
Scientific Editor Work List	83776-Scientific editor work list.pdf
CrossCheck Report	83776-CrossCheck report.pdf