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7/25/2023 9:02:00 AM | Browse: 236 | Download: 866
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Received |
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2023-04-08 08:56 |
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Peer-Review Started |
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2023-04-08 08:59 |
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To Make the First Decision |
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Return for Revision |
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2023-04-25 01:32 |
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Revised |
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2023-05-15 12:37 |
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Second Decision |
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2023-06-06 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-06-06 10:17 |
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Articles in Press |
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2023-06-06 10:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-07-18 03:24 |
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Publish the Manuscript Online |
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2023-07-25 06:43 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Zinc enhances the cell adhesion, migration, and self-renewal potential of human umbilical cord derived mesenchymal stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Iqra Sahibdad, Shumaila Khalid, G Rasul Chaudhry, Asmat Salim, Sumreen Begum and Irfan Khan |
| Funding Agency and Grant Number |
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| Corresponding Author |
Irfan Khan, PhD, Assistant Professor, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, University Road, Karachi 75270, Sindh, Pakistan. khan@iccs.edu |
| Key Words |
Human umbilical cord; Mesenchymal stem cells; Zinc; Cell proliferation; In vitro expansion |
| Core Tip |
Zinc (Zn) efficiently increased the proliferation of mesenchymal stem cells (MSCs) with a significant increase in the rate of population doublings, and at higher concentrations, it was cytotoxic. MSCs of the test group maintained a higher frequency of mesenchymal progenitors. Upregulation of genes involved in cell cycle, proliferation, pluripotency, and migration, was also observed in test groups. Zn increased the migration capability of MSCs and cell adhesion ability of MSCs. Overall, the results showed that Zn at lower concentrations supported cell growth, division, and proliferation of MSCs while maintaining the MSC-specific characteristics, including pluripotency, migration, and cell adhesion. |
| Publish Date |
2023-07-25 06:43 |
| Citation |
Sahibdad I, Khalid S, Chaudhry GR, Salim A, Begum S, Khan I. Zinc enhances the cell adhesion, migration, and self-renewal potential of human umbilical cord derived mesenchymal stem cells. World J Stem Cells 2023; 15(7): 751-767 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i7/751.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i7.751 |
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