Publication Name	World Journal of Gastroenterology
Manuscript ID	85076
Country	United States

Received	2023-04-10 18:19
Peer-Review Started	2023-04-10 18:19
To Make the First Decision
Return for Revision	2023-06-17 07:46
Revised	2023-07-21 03:21
Second Decision	2023-08-11 02:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-08-15 17:24
Articles in Press	2023-08-15 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-08-28 03:36
Publish the Manuscript Online	2023-09-01 08:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Very early onset perinatal constipation: Can it be cow’s milk protein allergy?
Manuscript Source	Invited Manuscript
All Author List	Rajalakshmy Arakoni, Hebat Kamal and Sam Xianjun Cheng
Funding Agency and Grant Number
Corresponding Author	Sam Xianjun Cheng, MD, MSc, PhD, Attending Doctor, Department of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Florida Shands Children's Hospital, 1600 SW Archer Rd, HD 606, Gainesville, FL 32608, United States. sam.cheng@ufl.edu
Key Words	Delayed passage of meconium; Perinatal constipation; Cow's milk protein allergy; In-utero; Alternate pathway; Hirschsprung’s disease
Core Tip	Cow’s milk protein allergy (CMPA) is a far lesser known cause of perinatal constipation compared to more frequently considered diagnoses such as Hirschsprung’s, Cystic fibrosis related meconium ileus, etc. The presentation during the perinatal period is considered atypical caused by a non-immunoglobulin E (IgE) mechanism as opposed to the typical presentation caused by an IgE-mediated mechanism. The likelihood of CMPA is significant in the perinatal period, therefore should be considered more often. Here we discuss an alternative pathway for the workup of perinatal constipation focusing on CMPA as an etiology. The use of this pathway can avoid invasive tests among patients.
Publish Date	2023-09-01 08:11
Citation	Arakoni R, Kamal H, Cheng SX. Very early onset perinatal constipation: Can it be cow’s milk protein allergy? World J Gastroenterol 2023; 29(33): 4920-4926
URL	https://www.wjgnet.com/1007-9327/full/v29/i33/4920.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i33.4920

Full Article (PDF)	WJG-29-4920-with-cover.pdf
Full Article (Word)	WJG-29-4920.docx
Manuscript File	85076_Auto_Edited-LM.docx
Answering Reviewers	85076-Answering reviewers.pdf
Audio Core Tip	85076-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	85076-Conflict-of-interest statement.pdf
Copyright License Agreement	85076-Copyright license agreement.pdf
Peer-review Report	85076-Peer-review(s).pdf
Scientific Misconduct Check	85076-Bing-Lin C-2.png
Scientific Editor Work List	85076-Scientific editor work list.pdf