| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Toxicology |
| Manuscript Type |
Basic Study |
| Article Title |
Green tea polyphenols alleviate di-(2-ethylhexyl) phthalate-induced liver injury in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Heng Shi, Xin-Hai Zhao, Qin Peng, Xian-Ling Zhou, Si-Si Liu, Chuan-Chuan Sun, Qiu-Yu Cao, Shi-Ping Zhu and Sheng-Yun Sun |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Department of Science and Technology, Science and Technology Plan Project, Journal of Jinan University High-Level Science and Technology Journal Construction Project |
2021B121020012 |
| Guangdong Provincial Administration of Traditional Chinese Medicine, Traditional Chinese Medicine Research Project |
20213005 |
|
| Corresponding Author |
Sheng-Yun Sun, MD, PhD, Chief Doctor, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Tianhe District, Guangzhou 522000, Guangdong Province, China. shengyunsun2020@163.com |
| Key Words |
Green tea polyphenols; Di(2-ethylhexyl) phthalate; Liver fibrosis; Fatty liver disease; Mitochondria; Immune |
| Core Tip |
Green tea polyphenols (GTPs) alleviated Di (2-ethylhexyl) phthalate (DEHP)-induced liver dysfunction, blood lipid dysregulation, fatty liver disease, liver fibrosis, and mitochondrial and endoplasmic reticulum lesions in mice. The infiltration of macrophages, mast cell, and natural killer cells varied between the model and treatment groups. mmu-miR-141-3p (a differentially expressed miRNA), Zcchc24 (a differentially expressed mRNA), and Zcchc24 (a differentially expressed protein) constituted the miRNA-mRNA-protein regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage in mice. |
| Publish Date |
2023-09-08 09:01 |
| Citation |
Shi H, Zhao XH, Peng Q, Zhou XL, Liu SS, Sun CC, Cao QY, Zhu SP, Sun SY. Green tea polyphenols alleviate di-(2-ethylhexyl) phthalate-induced liver injury in mice. World J Gastroenterol 2023; 29(34): 5054-5074 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i34/5054.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i34.5054 |
