Publication Name	World Journal of Clinical Cases
Manuscript ID	85867
Country	China

Received	2023-05-18 15:03
Peer-Review Started	2023-05-18 15:04
To Make the First Decision
Return for Revision	2023-07-03 08:28
Revised	2023-07-14 16:19
Second Decision	2023-08-03 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-08-03 07:47
Articles in Press	2023-08-03 07:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-08-04 08:13
Publish the Manuscript Online	2023-08-16 06:59

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Recent progress in understanding mitokines as diagnostic and therapeutic targets in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jiang Wang, Lan-Zhu Luo, Dao-Miao Liang, Chao Guo, Zhi-Hong Huang, Xiao-Hong Jian and Jie Wen
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Project of Hunan Education Department 21A0054
Corresponding Author	Jie Wen, PhD, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Key Words	Hepatocellular carcinoma; Mitochondria; Mitokine; Immune escape; Autophagy
Core Tip	The progression and metastasis of hepatocellular carcinoma (HCC) are intricately associated with alterations in mitochondrial metabolism. Mitokines, as critical cellular factors during mitochondrial stress, play an indispensable role in maintaining dynamic equilibrium within cells, intercellularly, and intertissue during mitochondrial stress. Through quantifying mitokine levels, we can assess the severity of HCC and predict the efficacy of treatment in HCC patients. The pursuit of highly specific and sensitive drugs targeting mitokines for HCC treatment represents a promising avenue for future research endeavors.
Publish Date	2023-08-16 06:59
Citation	Wang J, Luo LZ, Liang DM, Guo C, Huang ZH, Jian XH, Wen J. Recent progress in understanding mitokines as diagnostic and therapeutic targets in hepatocellular carcinoma. World J Clin Cases 2023; 11(23): 5416-5429
URL	https://www.wjgnet.com/2307-8960/full/v11/i23/5416.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i23.5416

Full Article (PDF)	WJCC-11-5416-with-cover.pdf
Full Article (Word)	WJCC-11-5416.docx
Manuscript File	85867_Auto_Edited-JLW.docx
Answering Reviewers	85867-Answering reviewers.pdf
Audio Core Tip	85867-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	85867-Conflict-of-interest statement.pdf
Copyright License Agreement	85867-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	85867-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	85867-Language certificate.pdf
Peer-review Report	85867-Peer-review(s).pdf
Scientific Misconduct Check	85867-Bing-Yan JP-2.png
Scientific Editor Work List	85867-Scientific editor work list.pdf
CrossCheck Report	85867-CrossCheck report.pdf