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9/20/2023 10:13:40 AM | Browse: 251 | Download: 672
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Received |
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2023-06-20 04:45 |
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Peer-Review Started |
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2023-06-20 04:48 |
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To Make the First Decision |
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Return for Revision |
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2023-08-26 16:50 |
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Revised |
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2023-09-01 03:27 |
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Second Decision |
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2023-09-07 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-09-07 07:23 |
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Articles in Press |
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2023-09-07 07:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-15 03:08 |
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Publish the Manuscript Online |
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2023-09-20 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ke Xu, Ai-Ru Yu, Shen-Bin Pan and Jie He |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Sichuan Province |
No. 2023NSFSC0729 |
| Wu Jieping Foundation Special Fund for Clinical Research |
No. 320.6750.2022-19-100 |
| Foundation of Key Clinical Specialty of Sichuan Province |
No. 2022 |
| School Foundation of Chengdu Medical College |
No. CYZYB21-05 |
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| Corresponding Author |
Jie He, PhD, Doctor, Doctor, Clinical Medical College, Chengdu Medical College, Baoguang street 278, Chengdu 610500, Sichuan Province, China. 2325@cmc.edu.cn |
| Key Words |
Branched chain amino acid transaminase 1; IKAROS family zinc finger 1; Methylation; Liquid biopsy; Colorectal cancer |
| Core Tip |
DNA methylation, a commonly used target for detecting ctDNA in plasma, is often explored as diagnostic biomarker of cancer. Here, the present study systematically analyzed 12 studies including 6561 individuals to assess the diagnostic value of methylated branched chain amino acid transaminase 1 (BCAT1)/ IKAROS family zinc finger 1 (IKZF1) in plasma for colorectal cancer (CRC) through meta-analysis. The sensitivity and specificity of methylated BCAT1/IKZF1 in plasma for CRC diagnosis were 60% [95% confidence interval (CI) 53-67] and 92% (95%CI 90-94), respectively. The detection of methylated BCAT1/IKZF1 has potential in CRC diagnosis, but the clinical application prospect needs to be explored. |
| Publish Date |
2023-09-20 10:11 |
| Citation |
Xu K, Yu AR, Pan SB, He J. Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer. World J Gastroenterol 2023; 29(36): 5240-5253 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i36/5240.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i36.5240 |
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