| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Location-based prediction model for Crohn’s disease regarding a novel serological marker, anti-chitinase 3-like 1 autoantibodies
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nora Sipeki, Patricia Julianna Kovats, Claudia Deutschmann, Peter Schierack, Dirk Roggenbuck and Maria Papp |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| German Federal Ministry of Education and Research (BMBF- Wachstumskern- PRAEMED.BIO) |
03WKDB2C |
| Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences |
BO/00232/17/5 |
| Research Grants of National Research Development and Innovation Office |
K115818/2015/1 |
| New National Excellence Program of the Ministry of Human Capacities |
ÚNKP-18-4 Bolyai Plus |
|
| Corresponding Author |
Nora Sipeki, MD, PhD, Assistant Lecturer, Attending Doctor, Doctor, Postdoc, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei blv 98, Debrecen H-4032, Hungary. sipeki.nora@med.unideb.hu |
| Key Words |
Chitinase 3-like 1 autoantibodies; Crohn’s disease; Ulcerative colitis; Disease progression; Immunoglobulin subtypes; Enzyme-linked immunosorbent assay |
| Core Tip |
The tolerance brake to chitinase 3-like 1 (CHI3L1), a novel neutrophil autoantigenic target in inflammatory bowel disease (IBD), the presence of immunoglobulin A (IgA) autoantibodies against this specific target, as well as the precise function and underlying processes of CHI3L1 in the development of IBD, continue to be uncertain. In the present prospective observational study, we first reported an enhanced formation of IgA and secretory IgA (sub)type against CHI3L1 in adult patients with Crohn’s disease, which was associated with the clinical phenotype and development of a complicated disease course during follow-up in a tertiary referral IBD center in Hungary. By taking into account the classes of antibodies and utilizing location-based predictions, serology in IBD may undergo a significant transformation in the future. |
| Publish Date |
2023-11-13 06:46 |
| Citation |
Sipeki N, Kovats PJ, Deutschmann C, Schierack P, Roggenbuck D, Papp M. Location-based prediction model for Crohn’s disease regarding a novel serological marker, anti-chitinase 3-like 1 autoantibodies. World J Gastroenterol 2023; 29(42): 5728-5750 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i42/5728.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i42.5728 |
