Publication Name	World Journal of Biological Chemistry
Manuscript ID	8668
Country	United States

Received	2014-01-02 10:15
Peer-Review Started	2014-01-02 17:28
To Make the First Decision	2014-01-23 17:10
Return for Revision	2014-02-09 21:10
Revised	2014-03-06 23:18
Second Decision	2014-05-19 09:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-19 09:23
Articles in Press	2014-05-23 08:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-29 15:16
Publish the Manuscript Online	2014-09-11 10:03

ISSN	1949-8454 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Critical role of bicarbonate and bicarbonate transporters in cardiac function
Manuscript Source	Invited Manuscript
All Author List	Hong-Sheng Wang, Yamei Chen, Kanimozhi Vairamani and Gary E Shull
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health Grants HL061974 (to Shull GE) National Institutes of Health Grants ES017263 (to Wang HS)
Corresponding Author	Gary E. Shull Department of Molecular Genetics, Biochemistry, and Microbiology, 231 Albert Sabin Way, Cincinnati, Ohio 45267-0524 United States Email: shullge@ucmail.uc.edu
Key Words	Cl-/HCO3- exchanger; Na+/HCO3- cotransporter; SLC4A; SLC26A; NBCe1
Core Tip	Bicarbonate is one of the major anions in mammalian tissues and extracellular fluids. It plays a critical role in pH homeostasis and can be utilized by a variety of ion transporters, often working in coupled systems, to transport other ions and organic substrates across cell membranes. Here we review studies of the identities and physiological functions of Cl-/HCO3- exchangers and Na+/HCO3- cotransporters in heart, and present RNA Seq analysis of their cardiac mRNA expression levels. These studies demonstrate that HCO3- and HCO3- handling proteins are abundant in heart and play important roles in the regulation of cardiac function.
Publish Date	2014-09-11 10:03
Citation	Wang HS, Chen Y, Vairamani K, Shull GE. Critical role of bicarbonate and bicarbonate transporters in cardiac function. World J Biol Chem 2014; 5(3): 334-345
URL	http://www.wjgnet.com/1949-8454/full/v5/i3/334.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i3.334

Full Article (PDF)	WJBC-5-334.pdf
Full Article (Word)	WJBC-5-334.doc
Manuscript File	8668-Review.docx
Answering Reviewers	8668-Answering reviewers.pdf
Copyright License Agreement	8668-Copyright assignment.pdf
Peer-review Report	8668-Peer review(s).pdf
Scientific Editor Work List	8668-Scientific editor work list.pdf