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9/14/2023 3:01:20 PM | Browse: 43 | Download: 45
Publication Name World Journal of Gastroenterology
Manuscript ID 86691
Country/Territory China
2023-07-02 10:25
Peer-Review Started
2023-07-02 10:26
To Make the First Decision
Return for Revision
2023-07-14 01:31
2023-07-22 14:24
Second Decision
2023-08-31 02:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-08-31 17:36
Articles in Press
2023-08-31 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-09-08 08:18
Publish the Manuscript Online
2023-09-14 14:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Lowering the threshold of alanine aminotransferase for enhanced identification of significant hepatic injury in chronic hepatitis B patients
Manuscript Source Unsolicited Manuscript
All Author List Hong-Sheng Yu, Hao Jiang, Ming-Kai Li, Bi-Lan Yang, Abdukyamu Smayi, Jian-Ning Chen, Bin Wu and Yi-Dong Yang
Funding Agency and Grant Number
Funding Agency Grant Number
The Natural Science Foundation of Guangdong Province for Distinguished Young Scholar 2022B1515020024
National Natural Science Foundation of China 82070574
The Natural Science Foundation Team Project of Guangdong Province 2018B030312009
Corresponding Author Yi-Dong Yang, PhD, Associate Professor, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, Guangdong Province, China. yangyd6@mail.sysu.edu.cn
Key Words Chronic hepatitis B; Grey zone; Indeterminate phase; Alanine aminotransferase; Antiviral therapy
Core Tip In clinical practice, 27.8%-55% of chronic hepatitis B patients fall into the “grey zone” or “indeterminate phase” that does not meet the diagnostic criteria of the traditional stages. Additionally, there is still debate regarding how best to treat these grey zone (GZ) patients and the advantages of antiviral therapy. Hence, we evaluated the clinical and histological characteristics, and additionally explored the impact of adjusting the threshold of alanine aminotransferase (ALT) in identifying significant liver injury among GZ patients. Based on these data, lowering ALT thresholds can more accurately identify patients with significant hepatic injury at an earlier stage and reduce the need for unnecessary liver biopsies.
Publish Date 2023-09-14 14:58
Citation Yu HS, Jiang H, Li MK, Yang BL, Smayi A, Chen JN, Wu B, Yang YD. Lowering the threshold of alanine aminotransferase for enhanced identification of significant hepatic injury in chronic hepatitis B patients. World J Gastroenterol 2023; 29(35): 5166-5177
URL https://www.wjgnet.com/1007-9327/full/v29/i35/5166.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i35.5166
Full Article (PDF) WJG-29-5166-with-cover.pdf
Full Article (Word) WJG-29-5166.docx
STROBE Statement 86691-STROBE statement.pdf
Manuscript File 86691_Auto_Edited-LM.docx
Answering Reviewers 86691-Answering reviewers.pdf
Audio Core Tip 86691-Audio core tip.aac
Biostatistics Review Certificate 86691-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 86691-Conflict-of-interest statement.pdf
Copyright License Agreement 86691-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 86691-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 86691-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 86691-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 86691-Language certificate.pdf
Supplementary Material 86691-Supplementary material.pdf
Peer-review Report 86691-Peer-review(s).pdf
Scientific Misconduct Check 86691-Bing-Fan JR-2.png
Scientific Editor Work List 86691-Scientific editor work list.pdf