Publication Name	World Journal of Gastroenterology
Manuscript ID	87029
Country	Russia

Received	2023-07-19 18:50
Peer-Review Started	2023-07-19 18:53
To Make the First Decision
Return for Revision	2023-08-05 12:31
Revised	2023-08-10 13:36
Second Decision	2023-09-14 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-09-14 08:33
Articles in Press	2023-09-14 08:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-09-01 09:31
Typeset the Manuscript	2023-09-19 08:44
Publish the Manuscript Online	2023-09-25 09:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage
Manuscript Source	Invited Manuscript
All Author List	Vasiliy Ivanovich Reshetnyak and Igor Veniaminovich Maev
Funding Agency and Grant Number
Corresponding Author	Vasiliy Ivanovich Reshetnyak, DSc, MD, PhD, Full Professor, Department of Propaedeutics of Internal Diseases and Gastroenterology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, No. 20 Delegatskaya St., Build. 1, Moscow 127473, Russia. vasiliy.reshetnyak@yandex.ru
Key Words	Primary biliary cholangitis; Antimitochondrial autoantibodies; MicroRNA 506; Inositol-1,4,5-trisphosphate receptor type 3; chloride/bicarbonate anion exchanger 2; Biliary bicarbonate umbrella; Dihydrolipoyl transacetylase (E2 subunit); Pyruvate dehydrogenase complex
Core Tip	This review considers the mechanisms contributing to the damage of the E2 subunit of the pyruvate dehydrogenase complex, formation of antimitochondrial autoantibodies (AMAs), and the development of ductulopenia in primary biliary cholangitis asymptomatic stage. A hypothesis explaining the pathogenesis of the initial morphological (ductulopenia), immunologic (AMAs), and clinical (weakness, malaise, rapid fatigue) signs of the disease in the asymptomatic stage is proposed.
Publish Date	2023-09-25 09:07
Citation	Reshetnyak VI, Maev IV. New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage. World J Gastroenterol 2023; 29(37): 5292-5304
URL	https://www.wjgnet.com/1007-9327/full/v29/i37/5292.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i37.5292

Full Article (PDF)	WJG-29-5292-with-cover.pdf
Full Article (Word)	WJG-29-5292.docx
Manuscript File	87029_Auto_Edited-XLQ-Webster J-JLW.docx
Answering Reviewers	87029-Answering reviewers.pdf
Audio Core Tip	87029-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	87029-Conflict-of-interest statement.pdf
Copyright License Agreement	87029-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	87029-Language certificate.pdf
Peer-review Report	87029-Peer-review(s).pdf
Scientific Misconduct Check	87029-Bing-Qu XL-2.png
Scientific Editor Work List	87029-Scientific editor work list.pdf