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12/19/2023 1:25:00 PM | Browse: 403 | Download: 1535
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Received |
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2023-08-26 08:36 |
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Peer-Review Started |
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2023-08-26 08:38 |
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2023-09-05 03:30 |
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2023-09-05 03:30 |
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2023-10-04 08:01 |
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2023-11-03 09:25 |
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2023-11-09 06:46 |
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Articles in Press |
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2023-11-09 06:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-08 05:15 |
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Publish the Manuscript Online |
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2023-12-19 13:19 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Case Control Study |
| Article Title |
Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin Li, Wen-Huan Xiao, Fei Ye, Xiao-Wei Tang, Qiu-Fang Jia and Xiao-Bin Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Suzhou Municipal Sci-Tech Bureau Program |
SS202070 |
| Scientific and Technological Program of Suzhou |
SS202069 |
| Suzhou clinical Medical Center for mood disorders |
Szlcyxzx202109 |
| Suzhou Clinical Key Disciplines for Geriatric Psychiatry |
SZXK202116 |
| Suzhou Key Technologies Program |
SKY2021063 |
| Jiangsu Province social development project |
BE2020764 |
| Research Project of Jiangsu Commission of Health |
M2020031 |
| Elderly Health Research Project of Jiangsu Commission of Health |
LR2022015 |
| Elderly Health Research Project of Jiangsu Commission of Health |
LKZ2023020 |
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| Corresponding Author |
Xiao-Bin Zhang, MD, PhD, Chief Physician, Department of Psychiatry, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com |
| Key Words |
Brain-derived neurotrophic factor; Clinical symptoms; Cognitive function; Schizophrenia; Sex hormones |
| Core Tip |
Brain-derived neurotrophic factor (BDNF) and sex hormones are known to be involved to the psychopathology of schizophrenia (SCZ). However, the influence of BDNF and sex hormones on cognition and symptoms in chronic antipsychotic-treated male (CATM) SCZ patients have yet to be investigated. Testosterone, prolactin (PRL) and luteinizing hormone were significantly higher in the patient group than in the healthy controls while estradiol (E2) levels were significantly lower. Analysis also identified positive correlations between E2 levels and BDNF levels, and BDNF levels and the digital cancellation time, in the whole sample. we found significant correlations between PRL levels and negative symptoms score in CATM patients with SCZ. |
| Publish Date |
2023-12-19 13:19 |
| Citation |
Li J, Xiao WH, Ye F, Tang XW, Jia QF, Zhang XB. Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy. World J Psychiatry 2023; 13(12): 995-1004
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| URL |
https://www.wjgnet.com/2220-3206/full/v13/i12/995.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v13.i12.995 |
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