Publication Name	World Journal of Otorhinolaryngology
Manuscript ID	88281
Country	Brazil

Received	2023-09-18 11:59
Peer-Review Started	2023-09-18 12:02
To Make the First Decision
Return for Revision	2023-12-12 07:52
Revised	2023-12-21 16:25
Second Decision	2024-01-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-05 06:18
Articles in Press	2024-01-05 06:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-12 02:10
Publish the Manuscript Online	2024-01-17 09:29

ISSN	2218-6247 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Otorhinolaryngology
Manuscript Type	Review
Article Title	Usher syndrome: Genetic diagnosis and current therapeutic approaches
Manuscript Source	Unsolicited Manuscript
All Author List	Beatriz Rocha Cuzzuol, Jonathan Santos Apolonio, Ronaldo Teixeira da Silva Júnior, Lorena Sousa de Carvalho, Luana Kauany de Sá Santos, Luciano Hasimoto Malheiro, Marcel Silva Luz, Mariana Santos Calmon, Henrique de Lima Crivellaro, Fabian Fellipe Bueno Lemos and Fabrício Freire de Melo
Funding Agency and Grant Number
Corresponding Author	Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormínio Barros, 58 Candeias, Vitória da Conquista 45029-094, Bahia, Brazil. freiremelo@yahoo.com.br
Key Words	Usher syndromes; Hearing loss; Retinitis pigmentosa; Diagnosis; Genetic therapies; Cochlear implantation; Quality of life
Core Tip	Usher syndrome (USH) is a genetically inherited condition characterized by both hearing loss and vision impairment, leading to restrictions in daily activities and social interactions. Therefore, gaining a comprehensive understanding of the genetic and molecular aspects of this syndrome is of utmost importance to facilitate early intervention and enhance the quality of life for affected individuals. This review aims to summarize the genetic and molecular diagnosis and current treatments of USH and underscore the significance of early diagnosis in guiding appropriate treatment approaches.
Publish Date	2024-01-17 09:29
Citation	Cuzzuol BR, Apolonio JS, da Silva Júnior RT, de Carvalho LS, Santos LKS, Malheiro LH, Silva Luz M, Calmon MS, Crivellaro HL, Lemos FFB, Freire de Melo F. Usher Syndrome: Genetic diagnosis and current therapeutic approaches. World J Otorhinolaryngol 2024; 11(1): 1-17
URL	https://www.wjgnet.com/2218-6247/full/v11/i1/1.htm
DOI	https://dx.doi.org/10.5319/wjo.v11.i1.1

Full Article (PDF)	WJO-11-1-with-cover.pdf
Full Article (Word)	WJO-11-1.docx
Manuscript File	88281_Auto_Edited-JLW.docx
Answering Reviewers	88281-Answering reviewers.pdf
Audio Core Tip	88281-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	88281-Conflict-of-interest statement.pdf
Copyright License Agreement	88281-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	88281-Language certificate.pdf
Peer-review Report	88281-Peer-review(s).pdf
Scientific Misconduct Check	88281-Bing-Chen YL-2.png
Scientific Editor Work List	88281-Scientific editor work list.pdf