Publication Name	World Journal of Gastroenterology
Manuscript ID	89027
Country	Japan

Received	2023-10-18 09:43
Peer-Review Started	2023-10-18 09:45
To Make the First Decision
Return for Revision	2023-12-11 07:34
Revised	2023-12-16 23:32
Second Decision	2024-01-18 02:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-18 05:19
Articles in Press	2024-01-18 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-25 12:35
Publish the Manuscript Online	2024-02-21 09:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Pathophysiology of severe gallstone pancreatitis: A new paradigm
Manuscript Source	Invited Manuscript
All Author List	Masatoshi Isogai
Funding Agency and Grant Number
Corresponding Author	Masatoshi Isogai, MD, Director, Department of Surgery, Clinic IB, No. 657-1 Ibigawa-cho Nagara, Ibi 501-0614, Gifu, Japan. masatoshi.isogai@gmail.com
Key Words	Gallstone pancreatitis; Biliary pancreatitis; Gallstone hepatitis; Acute cholangitis; Necrotizing pancreatitis; Pathophysiology
Core Tip	Gallstones represent the main cause of acute pancreatitis globally, and awareness of the etiology and pathogenesis of severe disease is mandatory. Based on the present study aimed to clarify the pathophysiology of severe disease from clinicopathological and historical points of view, severe gallstone pancreatitis may be a hybrid disease with pathology polarized between acute cholangitis and necrotizing pancreatitis in which the severity of hepatobiliary and pancreatic lesions is inversely related to the presence or absence of impacted ampullary stones with biliopancreatic obstruction. When the status of the stones is determined, the clinical course and outcome can be predicted.
Publish Date	2024-02-21 09:11
Citation	Isogai M. Pathophysiology of severe gallstone pancreatitis: A new paradigm. World J Gastroenterol 2024; 30(7): 614-623
URL	https://www.wjgnet.com/1007-9327/full/v30/i7/614.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i7.614

Full Article (PDF)	WJG-30-614-with-cover.pdf
Full Article (Word)	WJG-30-614.docx
Manuscript File	89027_Auto_Edited-YJP.docx
Answering Reviewers	89027-Answering reviewers.pdf
Audio Core Tip	89027-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	89027-Conflict-of-interest statement.pdf
Copyright License Agreement	89027-Copyright permission.pdf
Non-Native Speakers of English Editing Certificate	89027-Language certificate.pdf
Supplementary Material	89027-Supplementary material.pdf
Peer-review Report	89027-Peer-review(s).pdf
Scientific Misconduct Check	89027-Bing-Lin C-2.png
Scientific Editor Work List	89027-Scientific editor work list.pdf