Publication Name	World Journal of Orthopedics
Manuscript ID	90067
Country	China

Received	2023-11-24 07:49
Peer-Review Started	2023-11-22 10:50
To Make the First Decision
Return for Revision	2024-01-25 01:41
Revised	2024-02-04 06:53
Second Decision	2024-03-19 02:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-19 11:40
Articles in Press	2024-03-19 11:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-10 01:51
Publish the Manuscript Online	2024-04-16 08:04

ISSN	2218-5836 (online)
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Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Chang Zhou, Dong-Xue Wang, Chun-Yu Zhang, Ya-Jing Yang, Ruo-Bing Zhao, Sheng-Yao Liu and Guo-Xin Ni
Funding Agency and Grant Number	Funding Agency Grant Number the Key Laboratory of Sports and Physical Health of the Ministry of Education (Beijing Sport University), the Fundamental Research Funds for the Central Universities 20221021 the Guangzhou Science and Technology Plan Project 202102020536 the Plan on Enhancing Scientific Research in GMU
Corresponding Author	Guo-Xin Ni, MD, PhD, Chief Doctor, Chief Physician, Professor, Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen 361003, Fujian Province, China. nigx@xmu.edu.cn
Key Words	Exercise; Osteogenic differentiation; Bone formation; Bone mesenchymal stem cells; Autophagy
Core Tip	Adolescence is a critical period for laying the foundation for optimal peak bone mass in adulthood. Studies have shown that pre-puberty and early puberty are the periods when bones are most responsive to mechanical loading. It is essential to explore the effect of exercise on promoting bone formation in adolescence and its underlying mechanisms. In this paper, we explored the promotional effects of treadmill exercise on bone formation in growing mice and further explored the underlying mechanisms. Our results validate that moderate intensity running exercise is effective in stimulating bone formation and promoting increases in bone mineral density and bone mass, thereby enhancing peak bone mass in growing mice. Notably, the long non-coding RNA H19 (lncRNA H19)/microRNA-149 (miR-149) axis plays an important regulatory role in the osteogenic differentiation of bone mesenchymal stem cells. Overall, this paper emphasizes that exercise may promote bone formation in mice through the lncRNA H19/miR-149 axis, which may be closely related to the activation of autophagy.
Publish Date	2024-04-16 08:04
Citation	Zhou XC, Wang DX, Zhang CY, Yang YJ, Zhao RB, Liu SY, Ni GX. Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis. World J Orthop 2024; 15(4): 363-378
URL	https://www.wjgnet.com/2218-5836/full/v15/i4/363.htm
DOI	https://dx.doi.org/10.5312/wjo.v15.i4.363

Full Article (PDF)	WJO-15-363-with-cover.pdf
The ARRIVE Guidelines	90067-The ARRIVE guidelines.pdf
Manuscript File	90067_Auto_Edited-YJP.docx
Answering Reviewers	90067-Answering reviewers.pdf
Audio Core Tip	90067-Audio core tip.m4a
Biostatistics Review Certificate	90067-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90067-Conflict-of-interest statement.pdf
Copyright License Agreement	90067-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90067-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	90067-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	90067-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90067-Language certificate.pdf
Peer-review Report	90067-Peer-review(s).pdf
Scientific Misconduct Check	90067-CrossCheck.png
Scientific Misconduct Check	90067-Bing-Gong ZM-2.png
Scientific Editor Work List	90067-Scientific editor work list.pdf