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8/28/2014 2:00:00 PM | Browse: 562 | Download: 556
Publication Name World Journal of Gastroenterology
Manuscript ID 9017
Country/Territory Canada
Received
2014-01-16 15:13
Peer-Review Started
2014-01-16 18:37
To Make the First Decision
2014-02-28 17:44
Return for Revision
2014-03-07 21:39
Revised
2014-04-14 12:05
Second Decision
2014-06-13 15:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-13 16:14
Articles in Press
2014-06-13 16:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-08-14 14:54
Publish the Manuscript Online
2014-08-29 11:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Chronic hepatitis C and liver fibrosis
Manuscript Source Invited Manuscript
All Author List Giada Sebastiani, Konstantinos Gkouvatsos and Kostas Pantopoulos
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN 288283-2011 (to Pantopoulos K)
Fonds de la Recherche en Santé du Quebéc (FRSQ) to Gkouvatsos K
FRSQ to Sebastiani G
FRSQ to Pantopoulos K
Corresponding Author Correspondence to: Kostas Pantopoulos, PhD, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec H3T 1E2, Canada. kostas.pantopoulos@mcgill.ca
Key Words Hepatitis C virus; Liver fibrosis; Cirrhosis; Biopsy; Fibroscan
Core Tip Chronic hepatitis C is a leading cause of liver-related morbidity and mortality and predisposes to liver fibrosis, the excessive accumulation of extracellular matrix proteins. The staging of liver fibrosis is critical for the management and prognosis of patients. This review provides an update on hepatitis C virus (HCV) epidemiology, summarizes basic mechanisms of HCV-dependent liver fibrogenesis, and discusses common methods for assessment of liver fibrosis. While liver biopsy was until recently considered as the gold standard, novel non-invasive methods, including serum biomarkers, transient elastography and combination algorithms, are gradually being incorporated into new guidelines and are becoming standard of care.
Publish Date 2014-08-29 11:57
Citation Sebastiani G, Gkouvatsos K, Pantopoulos K. Chronic hepatitis C and liver fibrosis. World J Gastroenterol 2014; 20(32): 11033-11053
URL http://www.wjgnet.com/1007-9327/full/v20/i32/11033.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i32.11033
Full Article (PDF) WJG-20-11033.pdf
Full Article (Word) WJG-20-11033.doc
Manuscript File 9017-Review.docx
Answering Reviewers 9017-Answering reviewers.pdf
Copyright License Agreement 9017-Copyright assignment.pdf
Peer-review Report 9017-Peer review(s).pdf
Scientific Misconduct Check 9017-CrossCheck.jpg
Scientific Editor Work List 9017-Scientific editor work list.pdf