| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pan Zheng, Xue-Yang Li, Xiao-Yu Yang, Huan Wang, Ling Ding, Cong He, Jian-Hua Wan, Hua-Jing Ke, Nong-Hua Lu, Nian-Shuang Li and Yin Zhu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82260133 |
| National Natural Science Foundation of China |
82370661 |
| the Academic and Technical Leader of major disciplines in Jiangxi Province |
20225BCJ23021 |
| the Jiangxi Medicine Academy of Nutrition and Health Management |
2022-PYXM-01 |
| the Natural Science Foundation of Jiangxi Province, No. 20224ACB216004; and the Technological Innovation Team Cultivation Project of the First Affiliated Hospital of Nanchang University |
YFYKCTDPY202202 |
|
| Corresponding Author |
Yin Zhu, MD, PhD, Chief Doctor, Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17 YongWaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. ndyfy01977@ncu.edu.cn |
| Key Words |
Acute pancreatitis; RNA-sequencing; Experimental acute pancreatitis models; Inflammatory; Apoptosis; TLR and NOD-like signaling pathways |
| Core Tip |
AP is a critical emergency condition with no effective targeted therapeutic interventions currently available. Therefore, RNA sequencing (RNA-seq) was employed to investigate the molecular alterations in acute pancreatitis (AP), aiming to identify novel therapeutic strategies. The RNA-seq analysis showed a significant upregulation of TLR and NOD-like signaling pathways in AP, with crucial involvement of genes such as TLR7, IRF7, and MYD88. Notably, the TUBA1A and GADD45A genes were identified as key players in the apoptosis signaling pathway. Substantial evidence was provided through comprehensive validation using Gene Expression Omnibus Series datasets from human peripheral blood and mouse pancreatic tissues, as well as transgenic mouse models to examine inflammation and apoptosis-related molecules. This study offers fresh insights for future therapeutic approaches in managing AP and establishes new directions for subsequent fundamental investigations. |
| Publish Date |
2024-04-12 16:45 |
| Citation |
Zheng P, Li XY, Yang XY, Wang H, Ding L, He C, Wan JH, Ke HJ, Lu NH, Li NS, Zhu Y. Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models. World J Gastroenterol 2024; 30(14): 2038-2058 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i14/2038.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i14.2038 |
