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Articles Published Processes
12/20/2014 9:24:00 PM | Browse: 1681 | Download: 1972
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Received |
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2014-03-11 21:49 |
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Peer-Review Started |
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2014-03-12 09:34 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-04-15 01:16 |
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Revised |
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2014-05-22 23:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-08-28 09:59 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-08-28 10:24 |
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Articles in Press |
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2014-08-28 10:55 |
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Edit the Manuscript by Language Editor |
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2014-09-23 18:01 |
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Typeset the Manuscript |
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2014-12-10 12:13 |
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Publish the Manuscript Online |
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2014-12-20 19:42 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Elisabetta Ceni, Tommaso Mello and Andrea Galli |
| Funding Agency and Grant Number |
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| Corresponding Author |
Andrea Galli, MD, PhD, Gastroenterology Unit, Department of Experimental and Clinical Biochemical Sciences, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy. a.galli@dfc.unifi.it |
| Key Words |
Alcohol metabolism; Acetaldehyde; Reactive oxygen species; Alcohol liver disease; Protein adducts; Hepatic stellate cells; Fibrosis; CYP2E1; Therapy |
| Core Tip |
The goal of this article is to review the mechanisms of alcohol-mediated toxicity in parenchymal and non-parenchymal cells of the liver. Specifically, we highlight the effect of oxidative-ethanol metabolites such as acetaldehyde and reactive oxidative species in the development of fat accumulation, fibrosis and deranged immune response. |
| Publish Date |
2014-12-20 19:42 |
| Citation |
Ceni E, Mello T, Galli A. Pathogenesis of alcoholic liver disease: Role of oxidative metabolism. World J Gastroenterol 2014; 20(47): 17756-17772 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i47/17756.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i47.17756 |
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