Publication Name	World Journal of Gastroenterology
Manuscript ID	10120
Country	France

Received	2014-03-14 09:19
Peer-Review Started	2014-03-14 12:14
To Make the First Decision	2014-04-28 14:09
Return for Revision	2014-05-02 15:12
Revised	2014-05-14 12:44
Second Decision	2014-07-22 16:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-22 17:14
Articles in Press	2014-07-22 18:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-10 09:21
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Microbiology
Manuscript Type	Topic Highlights
Article Title	Archaea and the human gut: The new beginning of an old story
Manuscript Source	Invited Manuscript
All Author List	Nadia Gaci, Guillaume Borrel, William Tottey, Paul William O'Toole and Jean-François Brugère
Funding Agency and Grant Number	Funding Agency Grant Number PhD Scholarship from the French “Ministère de l’Enseignement Supérieur et de la Recherche” To Nadia Gaci Science Foundation Ireland through a postdoctoral grant of the Alimentary Pharmabiotic Centre to Guillaume Borrel PhD Scholarship of the European Union (UE) and the Auvergne Council (FEDER) to William Tottey Department Agriculture, Fisheries and Marine of the Government of Ireland to Paul W O’Toole
Corresponding Author	Jean-Fran?ois Brugère, PhD, EA-4678 CIDAM, Clermont Université, Université d’Auvergne, 28 Place Henri Dunant, BP 10448, F-63000 Clermont-Ferrand, France. jf.brugere@udamail.fr
Key Words	Human gut microbiota; Methanogens; Methanomassiliicoccus; Methanomethylophilus; Trimethylaminuria; Trimethylamine; Methane; Cardiovascular disease; Archaebiotics; probiotics
Core Tip	Archaea are naturally occurring components of the human gut microbiota, whose significance is now being reevaluated. An update of the current knowledge about the archaea from the human gut is provided, integrating the new order of methanogens, Methanomassiliicoccales. By its particular metabolism, this lineage is likely a depleting biological agent of trimethylamine (TMA), a gut microbiota metabolite derived from diet which is implicated in cardiovascular disease and trimethylaminuria. The recent provocative proposal of archaea as a new class of probiotics (archaebiotics) should promote interest in the third domain of life concerning its possible involvement in gut physiopathology and human health.
Publish Date	2014-11-20 20:51
Citation	Gaci N, Borrel G, Tottey W, O’Toole PW, Brugère JF. Archaea and the human gut: New beginning of an old story. World J Gastroenterol 2014; 20(43): 16062-16078
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16062.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16062

Full Article (PDF)	WJG-20-16062.pdf
Full Article (Word)	WJG-20-16062.doc
Manuscript File	10120-Review.docx
Answering Reviewers	10120-Answering reviewers.pdf
Copyright License Agreement	10120-Copyright assignment.pdf
Peer-review Report	10120-Peer review(s).pdf
Scientific Misconduct Check	10120-CrossCheck.jpg
Scientific Editor Work List	10120-Scientific editor work list.pdf