Publication Name	World Journal of Gastroenterology
Manuscript ID	10254
Country

Received	2014-03-21 21:28
Peer-Review Started	2014-03-23 09:52
First Decision by Editorial Office Director
Return for Revision	2014-04-15 02:21
Revised	2014-05-05 00:00
Publication Fee Transferred
Second Decision by Editor	2014-07-22 16:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-22 18:23
Articles in Press	2014-07-22 18:35
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-23 09:33
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker
Manuscript Source	Invited Manuscript
All Author List	Susen Burock, Pia Herrmann, Ina Wendler, Markus Niederstrasser, Klaus-Dieter Wernecke and Ulrike Stein
Funding Agency and Grant Number
Corresponding Author	Ulrike Stein, Professor, Experimental and Clinical Research Center, Charité University Medicine Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany. ustein@mdc-berlin.de
Key Words	Gastric cancer; Plasma; Circulating transcripts; MACC1; S100A4; Diagnosis; Prognosis; Survival
Core Tip	We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer Metastasis Associated in Colon Cancer 1 (MACC1) in a prospective study of gastric cancer patients. MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers. We discriminated tumor-free volunteers and gastric cancer patients (all P < 0.001, sensitivity 0.68 (95%CI: 0.45-0.85), specificity 0.89 (95%CI: 0.77-0.95) of each disease stage (P < 0.05 for each). Shorter survival correlated with high circulating MACC1 transcript levels (P = 0.0015). Thus, circulating MACC1 transcript levels in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival.
Publish Date	2015-01-07 11:07
Citation	Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Stein U. Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker. World J Gastroenterol 2015; 21(1): 333-341
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/333.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.333

Full Article (PDF)	WJG-21-333.pdf
Full Article (Word)	WJG-21-333.doc
Manuscript File	10254-Review.docx
Answering Reviewers	10254-Answering reviewers.pdf
Copyright License Agreement	10254-Copyright assignment.pdf
Peer-review Report	10254-Peer review.pdf
Scientific Misconduct Check	10254-CorssCheck.JPG
Scientific Editor Work List	10254-Scientific editor work list.pdf