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1/7/2015 11:06:00 AM | Browse: 1265 | Download: 1536
Publication Name World Journal of Gastroenterology
Manuscript ID 10343
Country/Territory China
Received
2014-03-27 11:50
Peer-Review Started
2014-03-27 21:17
To Make the First Decision
2014-05-29 19:07
Return for Revision
2014-06-03 16:59
Revised
2014-07-02 12:25
Second Decision
2014-08-28 09:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-08-28 10:05
Articles in Press
2014-08-28 10:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-09-18 04:03
Typeset the Manuscript
2014-12-22 19:26
Publish the Manuscript Online
2015-01-07 11:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Rheumatology
Manuscript Type Retrospective Study
Article Title Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations
Manuscript Source Unsolicited Manuscript
All Author List Bo-An Li, Jia Liu, Jun Hou, Jie Tang, Jian Zhang, Jun Xu, Yong-Ji Song, Ai-Xia Liu, Jing Zhao, Jing-Xia Guo, Lin Chen, Han Wang, Li-Hua Yang, Jie Lu and Yuan-Li Mao
Funding Agency and Grant Number
Corresponding Author Yuan-Li Mao, Professor, Center of Clinical Laboratory Medicine, 302 Military Hospital of China, 100 W 4th Ring Middle Rd, Beijing 100039, China. maoyuanli2013@163.com
Key Words Autoantibodies; Chronic hepatitis B; Autoimmune hepatitis; Primary biliary cirrhosis; Cirrhosis; Hepatocellular carcinoma
Core Tip We investigated the prevalence of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC)-related autoantibodies and their associations with clinical features in Chinese patients with chronic hepatitis B. Interestingly, and unexpectedly, we demonstrated that anti-nuclear antibodies (ANA), especially ANA-H, were significantly negatively associated with cirrhosis. Another interesting finding was that the prevalence of anti-promyelocytic leukemia protein antibodies was significantly different between hepatocellular carcinoma (HCC) (0%) and non-HCC patients (12.5%). In terms of analytic methods, for the first time we used an unequivocal dichotomy to cluster the autoantibodies into AIH and PBC profiles to delineate the bias of autoantibody expression for each case. The data showed that the PBC profile was strongly associated with cirrhosis.
Publish Date 2015-01-07 11:07
Citation Li BA, Liu J, Hou J, Tang J, Zhang J, Xu J, Song YJ, Liu AX, Zhao J, Guo JX, Chen L, Wang H, Yang LH, Lu J, Mao YL. Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations. World J Gastroenterol 2015; 21(1): 283-291
URL http://www.wjgnet.com/1007-9327/full/v21/i1/283.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i1.283
Full Article (PDF) WJG-21-283.pdf
Full Article (Word) WJG-21-283.doc
Manuscript File 10343-Review.docx
Answering Reviewers 10343-Answering reviewers.pdf
Copyright License Agreement 10343-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 10343-Language certificate.pdf
Peer-review Report 10343-Peer review(s).pdf
Scientific Misconduct Check 10343-CrossCheck.jpg
Scientific Editor Work List 10343-Scientific editor work list.pdf