Category |
Rheumatology |
Manuscript Type |
Retrospective Study |
Article Title |
Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Bo-An Li, Jia Liu, Jun Hou, Jie Tang, Jian Zhang, Jun Xu, Yong-Ji Song, Ai-Xia Liu, Jing Zhao, Jing-Xia Guo, Lin Chen, Han Wang, Li-Hua Yang, Jie Lu and Yuan-Li Mao |
Funding Agency and Grant Number |
|
Corresponding Author |
Yuan-Li Mao, Professor, Center of Clinical Laboratory Medicine, 302 Military Hospital of China, 100 W 4th Ring Middle Rd, Beijing 100039, China. maoyuanli2013@163.com |
Key Words |
Autoantibodies; Chronic hepatitis B; Autoimmune hepatitis; Primary biliary cirrhosis; Cirrhosis; Hepatocellular carcinoma |
Core Tip |
We investigated the prevalence of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC)-related autoantibodies and their associations with clinical features in Chinese patients with chronic hepatitis B. Interestingly, and unexpectedly, we demonstrated that anti-nuclear antibodies (ANA), especially ANA-H, were significantly negatively associated with cirrhosis. Another interesting finding was that the prevalence of anti-promyelocytic leukemia protein antibodies was significantly different between hepatocellular carcinoma (HCC) (0%) and non-HCC patients (12.5%). In terms of analytic methods, for the first time we used an unequivocal dichotomy to cluster the autoantibodies into AIH and PBC profiles to delineate the bias of autoantibody expression for each case. The data showed that the PBC profile was strongly associated with cirrhosis. |
Publish Date |
2015-01-07 11:07 |
Citation |
Li BA, Liu J, Hou J, Tang J, Zhang J, Xu J, Song YJ, Liu AX, Zhao J, Guo JX, Chen L, Wang H, Yang LH, Lu J, Mao YL. Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations. World J Gastroenterol 2015; 21(1): 283-291 |
URL |
http://www.wjgnet.com/1007-9327/full/v21/i1/283.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v21.i1.283 |