Publication Name	World Journal of Gastroenterology
Manuscript ID	10343
Country	China

Received	2014-03-27 11:50
Peer-Review Started	2014-03-27 21:17
First Decision by Editorial Office Director
Return for Revision	2014-06-03 16:59
Revised	2014-07-02 12:25
Publication Fee Transferred
Second Decision by Editor	2014-08-28 09:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-08-28 10:05
Articles in Press	2014-08-28 10:48
Edit the Manuscript by Language Editor	2014-09-18 04:03
Typeset the Manuscript	2014-12-22 19:26
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Rheumatology
Manuscript Type	Retrospective Study
Article Title	Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations
Manuscript Source	Unsolicited Manuscript
All Author List	Bo-An Li, Jia Liu, Jun Hou, Jie Tang, Jian Zhang, Jun Xu, Yong-Ji Song, Ai-Xia Liu, Jing Zhao, Jing-Xia Guo, Lin Chen, Han Wang, Li-Hua Yang, Jie Lu and Yuan-Li Mao
Funding Agency and Grant Number
Corresponding Author	Yuan-Li Mao, Professor, Center of Clinical Laboratory Medicine, 302 Military Hospital of China, 100 W 4th Ring Middle Rd, Beijing 100039, China. maoyuanli2013@163.com
Key Words	Autoantibodies; Chronic hepatitis B; Autoimmune hepatitis; Primary biliary cirrhosis; Cirrhosis; Hepatocellular carcinoma
Core Tip	We investigated the prevalence of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC)-related autoantibodies and their associations with clinical features in Chinese patients with chronic hepatitis B. Interestingly, and unexpectedly, we demonstrated that anti-nuclear antibodies (ANA), especially ANA-H, were significantly negatively associated with cirrhosis. Another interesting finding was that the prevalence of anti-promyelocytic leukemia protein antibodies was significantly different between hepatocellular carcinoma (HCC) (0%) and non-HCC patients (12.5%). In terms of analytic methods, for the first time we used an unequivocal dichotomy to cluster the autoantibodies into AIH and PBC profiles to delineate the bias of autoantibody expression for each case. The data showed that the PBC profile was strongly associated with cirrhosis.
Publish Date	2015-01-07 11:07
Citation	Li BA, Liu J, Hou J, Tang J, Zhang J, Xu J, Song YJ, Liu AX, Zhao J, Guo JX, Chen L, Wang H, Yang LH, Lu J, Mao YL. Autoantibodies in Chinese patients with chronic hepatitis B: Prevalence and clinical associations. World J Gastroenterol 2015; 21(1): 283-291
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/283.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.283

Full Article (PDF)	WJG-21-283.pdf
Full Article (Word)	WJG-21-283.doc
Manuscript File	10343-Review.docx
Answering Reviewers	10343-Answering reviewers.pdf
Copyright License Agreement	10343-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10343-Language certificate.pdf
Peer-review Report	10343-Peer review(s).pdf
Scientific Misconduct Check	10343-CrossCheck.jpg
Scientific Editor Work List	10343-Scientific editor work list.pdf