Publication Name	World Journal of Gastroenterology
Manuscript ID	10346
Country	Hungary

Received	2014-03-28 09:30
Peer-Review Started	2014-03-28 10:16
To Make the First Decision	2014-04-28 14:07
Return for Revision	2014-05-02 15:38
Revised	2014-05-27 21:11
Second Decision	2014-07-22 16:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-22 17:15
Articles in Press	2014-07-22 18:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-18 17:57
Publish the Manuscript Online	2014-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Alleviated mucosal and neuronal damage in a rat model of Crohn’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Petra Talapka, Lajos István Nagy, Alexandra Pál, Marietta Zita Poles, Anikó Berkó, Mária Bagyánszki, László Géza Puskás, Éva Fekete and Nikolett Bódi
Funding Agency and Grant Number	Funding Agency Grant Number Hungarian Scientific Research Fund OTKA PD 108309 (to Bódi N) European Union and the State of Hungary European Social Fund in the framework of TÁMOP “National Excellence Program” 4.2.4.A/2-11/1-2012-0001
Corresponding Author	Nikolett Bódi, PhD, Senior Lecturer, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary. bodiniki85@gmail.com
Key Words	Crohn’s disease; Experimental rat model; Heme oxygenase-1; Myenteric neurons; Repetitive relapsing inflammation
Core Tip	We report our first results derived from a newly developed rat model with chronic experimental colitis allowed us to modelling the recurring periods of recrudescence and remission in Crohn’s disease. Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Repetitive recurrent inflammations (RRI) were mimicked by repeated administrations of TNBS. This study demonstrates for the first time that experimentally provoked RRI develop preconditioning effect by speeding up mucosal healing and restoring myenteric neuronal injury. Decreased severity of gut inflammation after repeated TNBS treatments might be associated with the persistent up-regulation of heme-oxygenase 1 messenger RNA expression.
Publish Date	2014-12-02 10:46
Citation	Talapka P, Nagy LI, Pál A, Poles MZ, Berkó A, Bagyánszki M, Puskás LG, Fekete E, Bódi N. Alleviated mucosal and neuronal damage in a rat model of Crohn’s disease. World J Gastroenterol 2014; 20(44): 16690-16697
URL	http://www.wjgnet.com/1007-9327/full/v20/i44/16690.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i44.16690

Full Article (PDF)	WJG-20-16690.pdf
Full Article (Word)	WJG-20-16690.doc
Manuscript File	10346-Review.doc
Answering Reviewers	10346-Answering reviewers.pdf
Copyright License Agreement	10346-Copyright assignment.pdf
Peer-review Report	10346-Peer reivew(s).pdf
Scientific Misconduct Check	10346-CrossCheck.jpg
Scientific Editor Work List	10346-Scientific editor work list.pdf