Publication Name	World Journal of Immunology
Manuscript ID	10362
Country	Belgium

Received	2014-03-27 21:06
Peer-Review Started	2014-03-27 22:39
To Make the First Decision	2014-04-28 14:33
Return for Revision	2014-04-30 15:47
Revised	2014-05-12 22:46
Second Decision	2014-06-11 14:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-11 14:29
Articles in Press	2014-06-11 15:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-22 17:39
Publish the Manuscript Online	2014-07-27 18:55

ISSN	2219-2824 (online)
Open Access
Copyright
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Category	Immunology
Manuscript Type	Review
Article Title	CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells
Manuscript Source	Invited Manuscript
All Author List	Isabel T Vogel, Stefaan W Van Gool and Jan L Ceuppens
Funding Agency and Grant Number
Corresponding Author	Jan L Ceuppens, MD, Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. jan.ceuppens@uzleuven.be
Key Words	Regulatory T cells; Tolerance; Cytolytic T lymphocyte-associated antigen-4Ig; Anti-CD40L; Costimulation
Core Tip	Costimulation blockade (e.g., CD28/B7 and CD40/CD40L blockade) has been successfully used experimentally to induce tolerance to allo- or auto-antigens. Several studies suggest that effector T cells (Teff) and regulatory T cells (Treg) have different requirements regarding costimulation. While blockade of the CD40L receptor does not affect Treg cells and targets Teff cells, the effect of blocking the CD28/cytolytic T lymphocyte-associated antigen (CTLA)-4/B7 interaction (with CTLA-4Ig) is more difficult to predict and depends on the type, the strength and the stage of an immune process. Importantly, manipulating these costimulatory signals can therefore shift the Treg/Teff cell balance towards dominant Treg cell activity.
Publish Date	2014-07-27 18:55
Citation	Vogel IT, Van Gool SW, Ceuppens JL. CD28/CTLA-4/B7 and CD40/CD40L costimulation and activation of regulatory T cells. World J Immunol 2014; 4(2): 63-77
URL	http://www.wjgnet.com/2219-2824/full/v4/i2/63.htm
DOI	http://dx.doi.org/10.5411/wji.v4.i2.63

Full Article (PDF)	WJI-4-63.pdf
Full Article (Word)	WJI-4-63.doc
Manuscript File	10362-Review.docx
Answering Reviewers	10362-Answering reviewers.pdf
Copyright License Agreement	10362-Copyright assignment.pdf
Peer-review Report	10362-Peer review(s).pdf
Scientific Misconduct Check	10362-CrossCheck.jpg
Scientific Editor Work List	10362-Scientific editor work list.pdf