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11/17/2014 3:13:00 PM | Browse: 375 | Download: 358
Publication Name World Journal of Gastroenterology
Manuscript ID 10489
Country of Manuscript Source South Korea
Received
2014-04-02 19:59
Peer-Review Started
2014-04-02 21:42
To Make the First Decision
2014-04-28 14:13
Return for Revision
2014-05-03 19:36
Revised
2014-05-14 15:30
Second Decision
2014-06-23 10:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-23 10:12
Articles in Press
2014-06-23 10:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-10-31 17:15
Publish the Manuscript Online
2014-11-17 15:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model
Manuscript Source Unsolicited Manuscript
All Author List Hyeong-Geug Kim, Jung-Min Kim, Jong-Min Han, Jin-Seok Lee, Min-Kyung Choi, Dong-Soo Lee, Yeon-Hwa Park and Chang-Gue Son
Funding Agency and Grant Number
Funding Agency Grant Number
Oriental Medicine Research and Development Project, Ministry of Health and Welfare, South Korea HI12C-1920-01001
Corresponding author Chang-Gue Son, MD, PhD, Professor, Liver and Immunology Research center, Daejeon Oriental Hospital of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, South Korea. ckson@dju.kr
Keywords Alcohol abuse; Liver injury; Traditional Chinese Medicine; Fibrogenic cytokines; Hepato stellate cell
Core Tip We observed that the protective effect of Chunggan extract (CGX) on alcohol induced rat model of hepatic injury. In this study, 4 wk of alcohol consumptions markedly induced hepatic injury. Treatment with CGX significantly reverses and ameliorates pro-fibrogenic cytokines including transforming growth factor-?, platelet-derived growth factor-BB, and connective tissue growth factor. We also revealed the significant effects of alcohol metabolism related molecules by CGX treatment. The pharmacological actions were supported by in vitro assay that acetaldehyde stimulated HSC-T6 cell activation was normalized by CGX. Collectively our results suggest that CGX will be applicable to treat patients with alcoholic liver injury through amelioration of fibrotic changes and alcohol metabolisms.
Publish Date 2014-11-17 15:12
Citation Kim HG, Kim JM, Han JM, Lee JS, Choi MK, Lee DS, Park YH, Son CG. Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model. World J Gastroenterol 2014; 20(42): 15703-15714
Url http://www.wjgnet.com/1007-9327/full/v20/i42/15703.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i42.15703
Full Article (PDF) WJG-20-15703.pdf
Full Article (Word) WJG-20-15703.doc
Manuscript File 10489-Review.docx
Answering Reviewers 10489-Answering reviewers.pdf
Copyright License Agreement 10489-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140402135640.pdf
Non-Native Speakers of English Editing Certificate 10489-Language certificate.pdf
Peer-review Report 10489-Peer review.pdf
Scientific Misconduct Check 10489-CorssCheck.jpg
Scientific Editor Work List 10489-Scientific editor work list.pdf