Publication Name	World Journal of Gastroenterology
Manuscript ID	10489
Country	South Korea

Received	2014-04-02 19:59
Peer-Review Started	2014-04-02 21:42
First Decision by Editorial Office Director
Return for Revision	2014-05-03 19:36
Revised	2014-05-14 15:30
Publication Fee Transferred
Second Decision by Editor	2014-06-23 10:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-06-23 10:12
Articles in Press	2014-06-23 10:30
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-31 17:15
Publish the Manuscript Online	2014-11-17 15:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model
Manuscript Source	Unsolicited Manuscript
All Author List	Hyeong-Geug Kim, Jung-Min Kim, Jong-Min Han, Jin-Seok Lee, Min-Kyung Choi, Dong-Soo Lee, Yeon-Hwa Park and Chang-Gue Son
Funding Agency and Grant Number	Funding Agency Grant Number Oriental Medicine Research and Development Project, Ministry of Health and Welfare, South Korea HI12C-1920-01001
Corresponding Author	Chang-Gue Son, MD, PhD, Professor, Liver and Immunology Research center, Daejeon Oriental Hospital of Daejeon University, 22-5 Daehung-dong, Jung-gu, Daejeon 301-724, South Korea. ckson@dju.kr
Key Words	Alcohol abuse; Liver injury; Traditional Chinese Medicine; Fibrogenic cytokines; Hepato stellate cell
Core Tip	We observed that the protective effect of Chunggan extract (CGX) on alcohol induced rat model of hepatic injury. In this study, 4 wk of alcohol consumptions markedly induced hepatic injury. Treatment with CGX significantly reverses and ameliorates pro-fibrogenic cytokines including transforming growth factor-?, platelet-derived growth factor-BB, and connective tissue growth factor. We also revealed the significant effects of alcohol metabolism related molecules by CGX treatment. The pharmacological actions were supported by in vitro assay that acetaldehyde stimulated HSC-T6 cell activation was normalized by CGX. Collectively our results suggest that CGX will be applicable to treat patients with alcoholic liver injury through amelioration of fibrotic changes and alcohol metabolisms.
Publish Date	2014-11-17 15:12
Citation	Kim HG, Kim JM, Han JM, Lee JS, Choi MK, Lee DS, Park YH, Son CG. Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model. World J Gastroenterol 2014; 20(42): 15703-15714
URL	http://www.wjgnet.com/1007-9327/full/v20/i42/15703.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i42.15703

Full Article (PDF)	WJG-20-15703.pdf
Full Article (Word)	WJG-20-15703.doc
Manuscript File	10489-Review.docx
Answering Reviewers	10489-Answering reviewers.pdf
Copyright License Agreement	10489-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140402135640.pdf
Non-Native Speakers of English Editing Certificate	10489-Language certificate.pdf
Peer-review Report	10489-Peer review.pdf
Scientific Misconduct Check	10489-CorssCheck.jpg
Scientific Editor Work List	10489-Scientific editor work list.pdf