Publication Name	World Journal of Nephrology
Manuscript ID	10516
Country	United States

Received	2014-04-04 11:33
Peer-Review Started	2014-04-04 20:44
To Make the First Decision	2014-04-15 15:16
Return for Revision	2014-06-12 17:28
Revised	2014-06-25 04:11
Second Decision	2014-07-29 09:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-29 09:12
Articles in Press	2014-07-29 09:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-30 16:24
Publish the Manuscript Online	2014-10-19 20:47

ISSN	2220-6124 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Clinical Neurology
Manuscript Type	Randomized Controlled Trial
Article Title	Long-term outcome of ketoconazole and tacrolimus co-administration in kidney transplant patients
Manuscript Source	Invited Manuscript
All Author List	Enver Khan, Mary Killackey, Damodar Kumbala, Heather LaGuardia, Yong-Jun Liu, Huai-Zhen Qin, Brent Alper, Anil Paramesh, Joseph Buell and Rubin Zhang
Funding Agency and Grant Number
Corresponding Author	Rubin Zhang, MD, FASN, Professor of Clinical Medicine, Section of Nephrology, Department of Medicine, 1430 Tulane Ave, Box SL-45, New Orleans, LA 70112, United States. rzhang@tulane.edu
Key Words	Kidney transplant; Rejection; Survival; Tacrolimus Ketoconazole; Pharmacokinetics; Cytochrome P450
Core Tip	Tacrolimus is mainly metabolized by cytochrome P450 enzymes and ketoconazole is a potent inhibitor of P450. Transplant programs often use ketoconazole to reduce the tacrolimus dose and financial cost. Small short-term studies had previously supported such practice, but the long-term outcome are still lacking. We hereby report our center’s experience of this combination in kidney transplant recipients. Our study suggests that co-administration of ketoconazole and tacrolimus is associated with significantly higher incidence of acute rejection in kidney transplant recipients.
Publish Date	2014-10-19 20:47
Citation	Khan E, Killackey M, Kumbala D, LaGuardia H, Liu YJ, Qin HZ, Alper B, Paramesh A, Buell J, Zhang R. Long-term outcome of ketoconazole and tacrolimus co-administration in kidney transplant patients. World J Nephrol 2014; 3(3): 107-113
URL	http://www.wjgnet.com/2220-6124/full/v3/i3/107.htm
DOI	http://dx.doi.org/10.5527/wjn.v3.i3.107

Full Article (PDF)	WJN-3-107.pdf
Full Article (Word)	WJN-3-107.doc
Manuscript File	10516-Review.docx
Answering Reviewers	10516-Answering reviewers.pdf
Copyright License Agreement	10516-Copyright assignment.pdf
Peer-review Report	10516-Peer review(s).pdf
Scientific Misconduct Check	10516-CrossCheck.jpg
Scientific Editor Work List	10516-Scientific editor work list.pdf