Publication Name	World Journal of Orthopedics
Manuscript ID	10659
Country	United States

Received	2014-04-12 17:46
Peer-Review Started	2014-04-12 20:46
To Make the First Decision	2014-04-28 14:25
Return for Revision	2014-05-01 12:20
Revised	2014-05-28 05:09
Second Decision	2014-10-16 15:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-10-16 15:54
Articles in Press	2014-10-16 15:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-22 11:56
Publish the Manuscript Online	2015-03-19 18:29

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Review
Article Title	Biological response to prosthetic debris
Manuscript Source	Invited Manuscript
All Author List	Diana Bitar and Javad Parvizi
Funding Agency and Grant Number
Corresponding Author	Javad Parvizi, MD, FRCS, the Rothman Institute at Thomas Jefferson University, Department of Orthopaedic Surgery, 125 S 9th St. Suite 1000, Philadelphia, PA 19107, United States. research@rothmaninstitute.com
Key Words	Debris; Adverse reaction; Osteolysis; Macro­phages; Cytokines; Chemotaxis; Polyethylene; Phagocytosis
Core Tip	After a comprehensive review of joint arthroplasty history, this article outlines the fundamental pathophysiology of the debris-induced biological reaction common to all particles types. Furthermore, specific characteristics of polyethylene, metal, ceramic, and polymethylmethacrylate particles are stated separately with their associated clinical relevance. Lastly, future therapeutic strategies to down-regulate periprosthetic osteolysis are enumerated, including anti-inflammatory agents used to modulate the cytokines release, anti-osteolytic agents used to disintegrate osteoclasts morphology, and antioxidants used to demolish the free oxygen radicals produced by the activated macrophages. The reader will find an extensive literature review encompassing all aspects of the debris-induced hostile cellular reaction.
Publish Date	2015-03-19 18:29
Citation	Bitar D, Parvizi J. Biological response to prosthetic debris. World J Orthop 2015; 6(2): 172-189
URL	http://www.wjgnet.com/2218-5836/full/v6/i2/172.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i2.172

Full Article (PDF)	WJO-6-172.pdf
Full Article (Word)	WJO-6-172.doc
Manuscript File	10659-Review.docx
Answering Reviewers	10659-Answering reviewers.pdf
Copyright License Agreement	10659-Copyright assignment.pdf
Peer-review Report	10659-Peer review(s).pdf
Scientific Misconduct Check	10659-CrossCheck.jpg
Scientific Editor Work List	10659-Scientific editor work list.pdf