Publication Name	World Journal of Gastroenterology
Manuscript ID	10695
Country	South Korea

Received	2014-04-15 08:47
Peer-Review Started	2014-04-15 16:03
First Decision by Editorial Office Director
Return for Revision	2014-05-21 08:28
Revised	2014-06-08 00:00
Publication Fee Transferred
Second Decision by Editor	2014-07-11 17:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-11 17:12
Articles in Press	2014-07-11 17:30
Edit the Manuscript by Language Editor	2014-08-09 20:34
Typeset the Manuscript	2014-12-27 20:27
Publish the Manuscript Online	2015-01-18 16:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression
Manuscript Source	Unsolicited Manuscript
All Author List	Sehe Dong Lee, Jung Wan Choe, Beom Jae Lee, Myoung Hee Kang, Moon Kyung Joo, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Jae Seon Kim and Young-Tae Bak
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea R1102452 Korea University K1220161 experimental techniques from the Core Laboratory for Convergent Translational Research of College of Medicine
Corresponding Author	Beom Jae Lee, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Korea University Medical Center, 97 Gurodong-gil, Guro-gu, Seoul 152-703, South Korea. l85210@medimail.co.kr
Key Words	Butein; Colitis; Inflammatory bowel disease; Interleukin-6/signal transducer and activator of transcription 3; Matrix metalloproteinase-9
Core Tip	This study examined if butein, a naturally derived substance, has therapeutic effects in an animal model of inflammatory bowel disease, interleukin (IL)-10-/- mice. The results show that butein suppressed bowel inflammation and interfered with the IL-6/signal transducer and activator of transcription 3 and matrix metalloproteinase-9 pathways, suggesting that butein should be used to treat bowel inflammation-induced colon cancer. Although there have been several in vitro studies on tumor cells, there have been no in vivo studies examining the effect of butein on colitis in mice.
Publish Date	2015-01-18 16:09
Citation	Lee SD, Choe JW, Lee BJ, Kang MH, Joo MK, Kim JH, Yeon JE, Park JJ, Kim JS, Bak YT. Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression. World J Gastroenterol 2015; 21(2): 465-474
URL	http://www.wjgnet.com/1007-9327/full/v21/i2/465.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i2.465

Full Article (PDF)	WJG-21-465.pdf
Full Article (Word)	WJG-21-465.doc
Manuscript File	10695-Review.docx
Answering Reviewers	10695-Answering reviewers.pdf
Copyright License Agreement	10695-Copyright assignment.pdf
Peer-review Report	10695-Peer review.pdf
Scientific Misconduct Check	10695-CrossCheck.jpg
Scientific Editor Work List	10695-Scientific editor work list.pdf