Publication Name	World Journal of Nephrology
Manuscript ID	10816
Country	Italy

Received	2014-04-21 09:54
Peer-Review Started	2014-04-21 22:58
First Decision by Editorial Office Director
Return for Revision	2014-07-03 18:30
Revised	2014-11-07 00:00
Publication Fee Transferred
Second Decision by Editor	2014-11-14 09:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-11-19 10:51
Articles in Press	2014-11-19 10:51
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-25 16:53
Publish the Manuscript Online	2015-02-07 09:38

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Case Control Study
Article Title	Relationship of MTHFR gene polymorphisms with renal and cardiac disease
Manuscript Source	Invited Manuscript
All Author List	Francesca M Trovato, Daniela Catalano, Angela Ragusa, G Fabio Martines, Clara Pirri, Maria Antonietta Buccheri, Concetta Di Nora and Guglielmo M Trovato
Funding Agency and Grant Number
Corresponding Author	Guglielmo M Trovato, MD, Department of Internal Medicine, University of Catania, P.A. Via Sant’Orsola 30, 95100 Catania, Italy. trovato.eu@gmail.com
Key Words	Homocysteine; Glomerular filtration rate; Renal function; Mediterranean diet; Genetic; Methyle­netetrahydrofolate reductase polymorphism; Insulin resistance; Obesity; Left ventricular hypertrophy; Echo­cardiography
Core Tip	We investigated the effects of different me-thylenetetrahydrofolate reductase (MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial, and challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism.
Publish Date	2015-02-07 09:38
Citation	Trovato FM, Catalano D, Ragusa A, Martines GF, Pirri C, Buccheri MA, Di Nora C, Trovato GM. Relationship of MTHFR gene polymorphisms with renal and cardiac disease. World J Nephrol 2015; 4(1): 127-137
URL	http://www.wjgnet.com/2220-6124/full/v4/i1/127.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i1.127

Full Article (PDF)	WJN-4-1.pdf
Full Article (Word)	WJN-4-1.doc
Manuscript File	10816-Review.docx
Answering Reviewers	10816-Answering reviewers.pdf
Copyright License Agreement	10816-Copyright assignment.pdf
Peer-review Report	10816-Peer review(s).pdf
Scientific Misconduct Check	10816-CrossCheck.jpg
Scientific Editor Work List	10816-Scientific editor work list.pdf