Publication Name	World Journal of Gastroenterology
Manuscript ID	10838
Country	Chile

Received	2014-04-22 21:43
Peer-Review Started	2014-04-22 22:03
To Make the First Decision	2014-05-29 19:21
Return for Revision	2014-06-04 20:44
Revised	2014-06-06 04:18
Second Decision	2014-07-30 10:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-30 10:16
Articles in Press	2014-07-30 10:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-04 18:22
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Autobiography
Article Title	T3-induced liver AMP-activated protein kinase signaling: Redox dependency and upregulation of downstream targets
Manuscript Source	Unsolicited Manuscript
All Author List	Luis A Videla, Virginia Fernández, Pamela Cornejo, Romina Vargas, Paula Morales, Juan Ceballo, Alvaro Fischer, Nicolás Escudero and Oscar Escobar
Funding Agency and Grant Number	Funding Agency Grant Number National Commission for Scientific and Technological Research 1120034
Corresponding Author	Luis A Videla, Professor, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia Avenue 1027, Chile. lvidela@med.uchile.cl
Key Words	Liver; Thyroid hormone; N-acetylcysteine; AMP-activated protein kinase; Fatty acid oxidation
Core Tip	This work investigated the redox dependency and promotion of downstream targets in thyroid hormone (T3)-induced AMP-activated protein kinase (AMPK) signaling. T3 upregulates AMPK with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC. Accordingly, AMPK targets acetyl-CoA carboxylase and cyclic AMP response element binding protein are phosphorylated, with the concomitant carnitine palmitoyltransferase-1? activation and higher expression of peroxisome proliferator-activated receptor-? co-activator-1? and that of the fatty acid oxidation (FAO)-related enzymes. This lead to enhancement in the serum levels of ?-hydroxybutyrate, a surrogate marker for hepatic FAO, which represent a key molecular mechanism regulating energy dynamics to limit metabolic stresses.
Publish Date	2014-12-18 17:08
Citation	Videla LA, Fernández V, Cornejo P, Vargas R, Morales P, Ceballo J, Fischer A, Escudero N, Escobar O. T3-induced liver AMP-activated protein kinase signaling: Redox dependency and upregulation of downstream targets. World J Gastroenterol 2014; 20(46): 17416-17425
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17416.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17416

Full Article (PDF)	WJG-20-17416.pdf
Full Article (Word)	WJG-20-17416.doc
Manuscript File	10838-Review.docx
Answering Reviewers	10838-Answering reviewers.pdf
Copyright License Agreement	10838-Copyright assigment.pdf
Non-Native Speakers of English Editing Certificate	10838-Language certificate.pdf
Peer-review Report	10838-Peer review.pdf
Scientific Misconduct Check	10838-CorssCheck.jpg
Scientific Editor Work List	10838-Scientific editor work list.pdf