Publication Name	World Journal of Gastroenterology
Manuscript ID	11105
Country	Poland

Received	2014-05-05 08:33
Peer-Review Started	2014-05-05 22:52
To Make the First Decision	2014-06-10 13:27
Return for Revision	2014-06-15 14:39
Revised	2014-07-08 07:47
Second Decision	2014-09-05 16:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-05 17:06
Articles in Press	2014-09-05 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-09-24 18:50
Typeset the Manuscript	2014-12-04 14:09
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure
Manuscript Source	Unsolicited Manuscript
All Author List	Marek Saracyn, Marek Brytan, Robert Zdanowski, Tomasz Ząbkowski, Przemysław Dyrla, Janusz Patera, Stanisław Wojtuń, Wojciech Kozłowski and Zofia Wańkowicz
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Higher Education 216/KBL/12
Corresponding Author	Marek Saracyn, MD, PhD, Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, Szaserów St. 128, 04-141 Warsaw, Poland. msaracyn@interia.pl
Key Words	Nitric oxide; Acute hepatic failure; Nitric oxide synthase; Rat model; Galactosamine
Core Tip	We investigated the role of the nitric oxide (NO) pathway in the pathogenesis of acute hepatic failure (AHF). The precise pathomechanism of AHF is poorly understood. In our study, most liver function parameters improved both before and after the induction of liver damage following inhibition of the NO pathway. Prophylactic administration of the inhibitor was more effective in improving liver function parameters. On the other hand, stimulation of the NO pathway after liver damage, regardless of the donor dose used, also improved most liver function parameters. Therefore, the NO pathway significantly influences the development of experimental galactosamine-induced AHF.
Publish Date	2014-12-18 17:08
Citation	Saracyn M, Brytan M, Zdanowski R, Ząbkowski T, Dyrla P, Patera J, Wojtuń S, Kozłowski W, Wańkowicz Z. Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure. World J Gastroenterol 2014; 20(46): 17407-17415
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17407.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17407

Full Article (PDF)	WJG-20-17407.pdf
Full Article (Word)	WJG-20-17407.doc
Manuscript File	11105-Review.docx
Answering Reviewers	11105-Answering reviewers.pdf
Copyright License Agreement	11105-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11105-Language certificate.pdf
Peer-review Report	11105-Peer review(s).pdf
Scientific Misconduct Check	11105-CrossCheck.jpg
Scientific Editor Work List	11105-Scientific editor work list.pdf