Publication Name	World Journal of Gastroenterology
Manuscript ID	11106
Country	Australia

Received	2014-05-05 19:31
Peer-Review Started	2014-05-05 23:09
To Make the First Decision	2014-05-29 19:13
Return for Revision	2014-06-04 11:15
Revised	2014-06-24 07:27
Second Decision	2014-08-28 09:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-08-28 10:07
Articles in Press	2014-08-28 10:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-17 21:39
Publish the Manuscript Online	2014-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development
Manuscript Source	Invited Manuscript
All Author List	Chun-Meng Jiang, Chun-Wen Pu, Ya-Hui Hou, Zhe Chen, Mohammed Alanazy and Lionel Hebbard
Funding Agency and Grant Number	Funding Agency Grant Number Robert W Storr Bequest to Sydney Medical Foundation University of Sydney Cancer Council NSW 1069733 West Translational Cancer Research Centre Partner Program funded by the Cancer Institute, NSW
Corresponding Author	Dr. Lionel Hebbard, Senior Research Fellow, Liver Cancer and Metabolism Group Head, Storr Liver Unit, Westmead Millennium Institute, University of Sydney, PO Box 412, Darcy Road, Westmead, NSW 2145, Australia. lionel.hebbard@sydney.edu.au
Key Words	Nonalcoholic steatohepatitis; Hepatocellular carcinoma; Inflammation; Microbiome; Bile acids
Core Tip	Non alcoholic steatohepatitis (NASH) is a metabolic inflammatory disease the can often advance to liver cancer. Previously, it was assumed that obesity, hepatocyte cellular death and insulin resistance were the dominant drivers of NASH progression to hepatocellular carcinoma. Herein, we discuss the latest concepts concerning the gut microbiome and bile acids, which have now been shown to have a role in promoting hepatic inflammation, and subsequent liver tumor growth.
Publish Date	2014-12-02 10:46
Citation	Jiang CM, Pu CW, Hou YH, Chen Z, Alanazy M, Hebbard L. Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development. World J Gastroenterol 2014; 20(44): 16464-16473
URL	http://www.wjgnet.com/1007-9327/full/v20/i44/16464.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i44.16464

Full Article (PDF)	WJG-20-16464.pdf
Full Article (Word)	WJG-20-16464.doc
Manuscript File	11106-Review.docx
Answering Reviewers	11106-Answering reviewers.pdf
Copyright License Agreement	11106-Copyright assignment.pdf
Peer-review Report	11106-Peer review(s).pdf
Scientific Misconduct Check	11106-CrossCheck.jpg
Scientific Editor Work List	11106-Scientific editor work list.pdf