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Publication Name World Journal of Hepatology
Manuscript ID 11257
Country/Territory Italy
2014-05-12 08:39
Peer-Review Started
2014-05-13 20:58
To Make the First Decision
2014-06-18 18:31
Return for Revision
2014-06-19 13:24
2014-07-08 03:41
Second Decision
2014-08-31 16:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-08-31 17:09
Articles in Press
2014-08-31 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-30 16:18
Publish the Manuscript Online
2014-10-19 20:39
ISSN 1948-5182 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression
Manuscript Source Invited Manuscript
All Author List Rosa Zampino, Nicola Coppola, Grazia Cirillo, Adriana Boemio, Carmine Minichini, Aldo Marrone, Maria Stanzione, Mario Starace, Emanuele Durante-Mangoni, Evangelista Sagnelli, Luciano Restivo, Giovanna Salzillo, Maria Chiara Fascione, Riccardo Nevola, Emanuele Miraglia del Giudice and Luigi Elio Adinolfi
Funding Agency and Grant Number
Funding Agency Grant Number
Regione Campania, Italy
Corresponding author Luigi Elio Adinolfi, MD, Professor, Clinical Hospital of Marcianise, ASL Caserta, Rione Santella, 81025 Marcianise (CE), Italy. luigielio.adinolfi@unina2.it
Keywords Steatosis; Insulin resistance; Hepatitis B and C viruses co-infection; Patatin-like phospholipase domain-containing 3; Liver fibrosis
Core Tip We evaluated the prevalence and role of steatosis, insulin resistance and patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphisms on disease progression in hepatitis B and C viruses (HCV-HBV) co-infected patients. The data showed that HBV-HCV patients have lower levels of liver steatosis and insulin resistance than HCV mono-infected patients. HBV seems to interact with HCV reducing HCV replication and HCV-related metabolic features. Thus, the influence of HCV-related steatosis and insulin resistance as well as PNPLA3 polymorphism do not significantly impact liver fibrosis progression in HBV-HCV patients. The more rapid progression of liver fibrosis observed in HBV-HCV co-infected patients seems to be mostly associated with HBV infection.
Publish Date 2014-10-19 20:39
Citation Zampino R, Coppola N, Cirillo G, Boemio A, Minichini C, Marrone A, Stanzione M, Starace M, Durante-Mangoni E, Sagnelli E, Restivo L, Salzillo G, Fascione MC, Nevola R, del Giudice EM, Adinolfi LE. Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression. World J Hepatol 2014; 6(9): 677-684
Url http://www.wjgnet.com/1948-5182/full/v6/i9/677.htm
DOI http://dx.doi.org/10.4254/wjh.v6.i9.677
Full Article (PDF) WJH-6-677.pdf
Full Article (Word) WJH-6-677.doc
Manuscript File 11257-Review.docx
Answering Reviewers 11257-Answering reviewers.pdf
Copyright License Agreement 11257-Copyright assignment.pdf
Peer-review Report 11257-Peer review(s).pdf
Scientific Misconduct Check 11257-CrossCheck.jpg
Scientific Editor Work List 11257-Scientific editor work list.pdf