Publication Name	World Journal of Gastroenterology
Manuscript ID	11260
Country	United States

Received	2014-05-12 11:11
Peer-Review Started	2014-05-12 13:57
To Make the First Decision	2014-05-22 11:03
Return for Revision	2014-05-22 11:36
Revised	2014-05-22 12:00
Second Decision	2014-06-13 12:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-13 12:10
Articles in Press	2014-06-13 12:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-22 18:06
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance
Manuscript Source	Invited Manuscript
All Author List	Mohtashem Samsam, Raheleh Ahangari and Saleh A Naser
Funding Agency and Grant Number
Corresponding Author	Saleh A Naser, PhD, Professor, Editor-in-Chief, Burnett School of Biomedical Sciences (BSBS), College of Medicine, University of Central Florida, Building 20, BMS 136, 4110 Libra Dr., Orlando, FL 32816, United States. saleh.naser@ucf.edu
Key Words	Autism spectrum disorders; Gastrointestinal abnormalities; Immune activation; Crohn’s disease; Neuropeptides; Brain-derived neurotrophic factor; Mycobacterium paratuberculosis
Core Tip	According to the March 2012 report released by United States Centers for Disease Control and Prevention there was a 78% increase in the prevalence of autism spectrum disorders (ASD) during 2002-2008 in the United States. Although several genes causing ASD have been discovered, genetic cause of ASD is about 25% of cases. There was not a significant research focus on environmental factors and ASD-associated co-morbidities in the last two decades. We revisited the gastrointestinal (GI) involvement, GI infection, immune imbalance, maternal infection and immunity, and intestinal microflora in ASD. Some neuropeptides, neurotrophins, their effects, and side effects have also been discussed.
Publish Date	2014-08-07 10:34
Citation	Samsam M, Ahangari R, Naser SA. Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance. World J Gastroenterol 2014; 20(29): 9942-9951
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9942.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9942

Full Article (PDF)	WJG-20-9942.pdf
Full Article (Word)	WJG-20-9942.doc
Manuscript File	11260-Review.docx
Answering Reviewers	10260-Answering reviewers.pdf
Copyright License Agreement	10260-Copyright assignment.pdf
Peer-review Report	11260-Peer review.pdf
Scientific Misconduct Check	11260-CorssCheck.jpg
Scientific Editor Work List	11260-Scientific editor work list.pdf