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8/25/2014 2:47:00 PM | Browse: 1062 | Download: 1078
Publication Name World Journal of Gastroenterology
Manuscript ID 11260
Country/Territory United States
Received
2014-05-12 11:11
Peer-Review Started
2014-05-12 13:57
To Make the First Decision
2014-05-22 11:03
Return for Revision
2014-05-22 11:36
Revised
2014-05-22 12:00
Second Decision
2014-06-13 12:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-13 12:10
Articles in Press
2014-06-13 12:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-07-22 18:06
Publish the Manuscript Online
2014-08-07 10:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance
Manuscript Source Invited Manuscript
All Author List Mohtashem Samsam, Raheleh Ahangari and Saleh A Naser
Funding Agency and Grant Number
Corresponding Author Saleh A Naser, PhD, Professor, Editor-in-Chief, Burnett School of Biomedical Sciences (BSBS), College of Medicine, University of Central Florida, Building 20, BMS 136, 4110 Libra Dr., Orlando, FL 32816, United States. saleh.naser@ucf.edu
Key Words Autism spectrum disorders; Gastrointestinal abnormalities; Immune activation; Crohn’s disease; Neuropeptides; Brain-derived neurotrophic factor; Mycobacterium paratuberculosis
Core Tip According to the March 2012 report released by United States Centers for Disease Control and Prevention there was a 78% increase in the prevalence of autism spectrum disorders (ASD) during 2002-2008 in the United States. Although several genes causing ASD have been discovered, genetic cause of ASD is about 25% of cases. There was not a significant research focus on environmental factors and ASD-associated co-morbidities in the last two decades. We revisited the gastrointestinal (GI) involvement, GI infection, immune imbalance, maternal infection and immunity, and intestinal microflora in ASD. Some neuropeptides, neurotrophins, their effects, and side effects have also been discussed.
Publish Date 2014-08-07 10:34
Citation Samsam M, Ahangari R, Naser SA. Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance. World J Gastroenterol 2014; 20(29): 9942-9951
URL http://www.wjgnet.com/1007-9327/full/v20/i29/9942.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i29.9942
Full Article (PDF) WJG-20-9942.pdf
Full Article (Word) WJG-20-9942.doc
Manuscript File 11260-Review.docx
Answering Reviewers 10260-Answering reviewers.pdf
Copyright License Agreement 10260-Copyright assignment.pdf
Peer-review Report 11260-Peer review.pdf
Scientific Misconduct Check 11260-CorssCheck.jpg
Scientific Editor Work List 11260-Scientific editor work list.pdf