Publication Name	World Journal of Gastroenterology
Manuscript ID	11305
Country	Japan

Received	2014-05-14 20:44
Peer-Review Started	2014-05-14 21:33
To Make the First Decision	2014-06-10 13:32
Return for Revision	2014-06-12 21:03
Revised	2014-06-16 13:28
Second Decision	2014-07-16 17:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-16 17:37
Articles in Press	2014-07-16 17:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-15 18:48
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Case Report
Article Title	Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Takuma Nomiya, Hiroko Akamatsu, Mayumi Harada, Ibuki Ota, Yasuhito Hagiwara, Mayumi Ichikawa, Misako Miwa, Shouhei Kawashiro, Motohisa Hagiwara, Masahiro Chin, Eiji Hashizume and Kenji Nemoto
Funding Agency and Grant Number
Corresponding Author	Takuma Nomiya, MD, PhD, Department of Radiation Oncology, National Institute of Radiological Sciences, Research Center Hospital for Charged Particle Therapy, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan. t_nomiya@nirs.go.jp
Key Words	Clinical trial; Image-guided radiotherapy; Rectal neoplasms; Quality of life; Neoplasm recurrence
Core Tip	This paper introduces a new technique of radiation therapy for huge tumors. In the past, patients with radioresistant huge adenocarcinoma could undergo only palliative treatment because huge tumors could not be controlled with a dose less than tolerant dose of healthy tissue. However, this technique enabled to deliver higher-dose to the center of huge tumor without exceeding tolerant dose to the healthy tissue. Of course it is difficult to cure these patients, this technique showed a possibility to control huge tumors. From the patients enrolled in this clinical trial, we introduce a patient with tumor arising from digestive system.
Publish Date	2015-01-06 09:08
Citation	Nomiya T, Akamatsu H, Harada M, Ota I, Hagiwara Y, Ichikawa M, Miwa M, Kawashiro S, Hagiwara M, Chin M, Hashizume E, Nemoto K. Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma. World J Gastroenterol 2014; 20(48): 18480-18486
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18480.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18480

Full Article (PDF)	WJG-20-18480.pdf
Full Article (Word)	WJG-20-18480.doc
Manuscript File	11305-Review.docx
Answering Reviewers	11305-Answering reviewers.pdf
Copyright License Agreement	11305-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140514143813.pdf
Non-Native Speakers of English Editing Certificate	11305-Language certificate.pdf
Peer-review Report	11305-Peer review.pdf
Scientific Misconduct Check	11305-CorssCheck.jpg
Scientific Editor Work List	11305-Scientific editor work list.pdf