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Articles Published Processes
12/2/2015 12:17:00 PM | Browse: 1317 | Download: 1534
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Received |
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2014-05-29 09:09 |
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Peer-Review Started |
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2014-05-29 13:57 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-07-30 11:24 |
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Revised |
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2014-09-01 18:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-10-10 18:04 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-10-10 18:18 |
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Articles in Press |
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2014-10-10 18:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-20 09:12 |
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Publish the Manuscript Online |
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2014-12-02 12:16 |
| Category |
Immunology |
| Manuscript Type |
Autobiography |
| Article Title |
Identification of host miRNAs that may limit human rhinovirus replication
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Victor Paky Bondanese, Ana Francisco-Garcia, Nicole Bedke, Donna E Davies and Tilman Sanchez-Elsner |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MRC |
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| AAIR |
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| Roger Brooke charitable trust |
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| Corresponding Author |
Dr. Tilman Sanchez-Elsner, PhD, Senior Lecturer in Biomedical Sciences, Academic Unit of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD,
United Kingdom. t.sanchez-elsner@soton.ac.uk
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| Key Words |
Human Rhinovirus; MicroRNAs; MiR-155; SiRNA; Lentiviral transduction; Antiviral innate immunity |
| Core Tip |
Our results show for the first time that: (1) DICER knock-down increases HRV-1B replication in human bronchial epithelial cells; (2) the genomic RNA of human rhinovirus (HRV)-1B interacts directly with the miRISC during infection; and (3) inhibition of two microRNAs predicted to target HRV-1B, i.e., miR-128 and miR-155, favors viral replication. This supports a role for cellular microRNAs in the antiviral response to HRV-1B mounted by bronchial epithelial cells, and suggests that pathological microRNA dysregulation may contribute to the poor antiviral immunity in diseases such as asthma and chronic obstructive pulmonary disease. |
| Publish Date |
2014-12-02 12:16 |
| Citation |
Bondanese VP, Francisco-Garcia A, Bedke N, Davies DE, Sanchez-Elsner T. Identification of host miRNAs that may limit human rhinovirus replication. World J Biol Chem 2014; 5(4): 437-456 |
| URL |
http://www.wjgnet.com/1949-8454/full/v5/i4/437.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v5.i4.437 |
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