Publication Name	World Journal of Biological Chemistry
Manuscript ID	11665
Country	United Kingdom

Received	2014-05-29 09:09
Peer-Review Started	2014-05-29 13:57
To Make the First Decision	2014-07-29 12:01
Return for Revision	2014-07-30 11:24
Revised	2014-09-01 18:45
Second Decision	2014-10-10 18:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-10-10 18:18
Articles in Press	2014-10-10 18:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 09:12
Publish the Manuscript Online	2014-12-02 12:16

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Immunology
Manuscript Type	Autobiography
Article Title	Identification of host miRNAs that may limit human rhinovirus replication
Manuscript Source	Invited Manuscript
All Author List	Victor Paky Bondanese, Ana Francisco-Garcia, Nicole Bedke, Donna E Davies and Tilman Sanchez-Elsner
Funding Agency and Grant Number	Funding Agency Grant Number MRC AAIR Roger Brooke charitable trust
Corresponding Author	Dr. Tilman Sanchez-Elsner, PhD, Senior Lecturer in Biomedical Sciences, Academic Unit of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom. t.sanchez-elsner@soton.ac.uk
Key Words	Human Rhinovirus; MicroRNAs; MiR-155; SiRNA; Lentiviral transduction; Antiviral innate immunity
Core Tip	Our results show for the first time that: (1) DICER knock-down increases HRV-1B replication in human bronchial epithelial cells; (2) the genomic RNA of human rhinovirus (HRV)-1B interacts directly with the miRISC during infection; and (3) inhibition of two microRNAs predicted to target HRV-1B, i.e., miR-128 and miR-155, favors viral replication. This supports a role for cellular microRNAs in the antiviral response to HRV-1B mounted by bronchial epithelial cells, and suggests that pathological microRNA dysregulation may contribute to the poor antiviral immunity in diseases such as asthma and chronic obstructive pulmonary disease.
Publish Date	2014-12-02 12:16
Citation	Bondanese VP, Francisco-Garcia A, Bedke N, Davies DE, Sanchez-Elsner T. Identification of host miRNAs that may limit human rhinovirus replication. World J Biol Chem 2014; 5(4): 437-456
URL	http://www.wjgnet.com/1949-8454/full/v5/i4/437.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i4.437

Full Article (PDF)	WJBC-5-437.pdf
Full Article (Word)	WJBC-5-437.doc
Manuscript File	11665-Review.docx
Answering Reviewers	11665-Answering reviewers.pdf
Copyright License Agreement	11665-Copyright assignment.pdf
Peer-review Report	11665-Peer review(s).pdf
Scientific Misconduct Check	11665-CrossCheck.jpg
Scientific Editor Work List	11665-Scientific editor work list.pdf