Publication Name	World Journal of Nephrology
Manuscript ID	11892
Country	Netherlands

Received	2014-06-11 08:27
Peer-Review Started	2014-06-11 14:15
To Make the First Decision	2014-06-27 11:51
Return for Revision	2014-06-27 19:34
Revised	2014-07-08 20:30
Second Decision	2014-08-31 16:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-08-31 17:11
Articles in Press	2014-08-31 17:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-23 09:56
Publish the Manuscript Online	2014-11-07 16:40

ISSN	2220-6124 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Minireviews
Article Title	T-cell ageing in end-stage renal disease patients: Assessment and clinical relevance
Manuscript Source	Invited Manuscript
All Author List	Ruud WJ Meijers, Michiel GH Betjes, Carla C Baan and Nicolle HR Litjens
Funding Agency and Grant Number
Corresponding Author	Ruud WJ Meijers, MSc, Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Centre, Room NA-523, PO Box 2040, 3000 CA Rotterdam, The Netherlands. r.meijers@erasmusmc.nl
Key Words	End-stage renal disease patients; Kidney transplantation; T-cell ageing; T-cell differentiation; Uremia
Core Tip	The uremia-induced inflammatory environment in end-stage renal disease (ESRD) patients is associated with a prematurely aged T-cell compartment, resulting in defective T-cell-mediated immunity. ESRD patients are highly susceptible for infections, have an increased risk for virus-associated cancers, respond poorly to vaccination and have an increased risk for atherosclerotic diseases. Adequate renal replacement therapy in the form of kidney transplantation is able to diminish the uremic pro-inflammatory environment but unsuccessfully reverses the aged T-cell system. Assessment of T-cell ageing might be a tool to facilitate individualization of immunosuppressive regimes and prevent over-immunosuppression and its associated clinical complications in kidney transplant recipients.
Publish Date	2014-11-07 16:40
Citation	Meijers RWJ, Betjes MGH, Baan CC, Litjens NHR. T-cell ageing in end-stage renal disease patients: Assessment and clinical relevance. World J Nephrol 2014; 3(4): 268-276
URL	http://www.wjgnet.com/2220-6124/full/v3/i4/268.htm
DOI	http://dx.doi.org/10.5527/wjn.v3.i4.268

Full Article (PDF)	WJN-3-268.pdf
Full Article (Word)	WJN-3-268.doc
Manuscript File	11892-Review.docx
Answering Reviewers	Answers reviewers 2.docx
Copyright License Agreement	BPG_Copyright_Assignment_11892 final.pdf