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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 1200 | Download: 1187
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Received |
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2014-06-12 08:28 |
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Peer-Review Started |
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2014-06-12 18:17 |
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To Make the First Decision |
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2014-07-09 12:01 |
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Return for Revision |
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2014-07-15 11:15 |
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Revised |
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2014-07-30 22:26 |
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Second Decision |
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2014-10-15 12:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-15 17:44 |
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Articles in Press |
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2014-10-15 17:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-30 09:54 |
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Typeset the Manuscript |
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2015-03-25 19:56 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nicholas G Theodorakis, Yining N Wang, Vyacheslav A Korshunov, Mary A Maluccio and Nicholas J Skill |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Departments of Surgery at the University of Rochester and Indiana University |
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| Corresponding Author |
Nicholas J Skill, PhD, Assistant Professor, Division of Transplant Surgery, Department of Surgery, School of Medicine, Indiana University, C519, 980 West Walnut Street (R3), Indianapolis, IN 46202, United States. nskill@iupui.edu |
| Key Words |
Portal hypertension; Thalidomide; Nitric oxide; Knockout mice; Endothelial nitric oxide synthase; Inducible nitric oxide synthase; Tumor necrosis factor alpha |
| Core Tip |
The research innovation detailed in this manu?script is the use of nitric oxide synthase (NOS) isoform specific gene deleted mice to better understand the underlying mechanisms for the development of portal hypertension (PHT). PHT is a significant complication of liver disease and increases morbidity and mortality. Our study examined the hypothesis that the compound thalidomide reduces PHT by decreasing the biosynthesis of nitric oxide (NO) via destabilizing tumor necrosis factor alpha mRNA levels. We demonstrate that thalidomide induces NO via increased inducible nitric oxide synthase isoform of NOS; however, thalidomide reduction in PHT was NOS isoform independent. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Theodorakis NG, Wang YN, Korshunov VA, Maluccio MA, Skill NJ. Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure. World J Gastroenterol 2015; 21(14): 4126-4135 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4126.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4126 |
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