Publication Name	World Journal of Gastroenterology
Manuscript ID	12069
Country	Italy

Received	2014-06-20 08:26
Peer-Review Started	2014-06-20 20:55
To Make the First Decision	2014-07-21 13:29
Return for Revision	2014-07-28 15:14
Revised	2014-08-01 21:57
Second Decision	2014-09-30 09:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-30 10:16
Articles in Press	2014-09-30 10:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-11-17 01:59
Typeset the Manuscript	2015-01-15 15:49
Publish the Manuscript Online	2015-01-27 15:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Metabolic shift in liver: Correlation between perfusion temperature and hypoxia inducible factor-1α
Manuscript Source	Unsolicited Manuscript
All Author List	Andrea Ferrigno, Laura Giuseppina Di Pasqua, Alberto Bianchi, Plinio Richelmi and Mariapia Vairetti
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione Cariplo 2011-0439
Corresponding Author	Andrea Ferrigno, PhD, Unit of Cellular and Molecular Pharmacology and Toxicology, Department of Internal Medicine and Therapeutics, University of Pavia, via Ferrata 9/A, Pavia 27100, Italy. andrea.ferrigno@unipv.it
Key Words	Anaerobiosis; Hypoxia inducible factor-1α; Ischemia; Liver transplantation; Machine perfusion
Core Tip	Among the techniques developed to improve the preservation of marginal organs for transplantation, hypothermic perfusion is the preferred choice. We show that it is possible to perfuse a rat liver at 20 ℃ without incurring ischemia. We evaluated liver injury, energetic status, lactate release, and hypoxia inducible factor-1? expression. Results show that symptoms of ischemia appear at temperatures > 20 ℃, whereas there is no detectable advantage below 20 ℃. These findings have interesting implications in liver preservation; maintaining the liver in a mild metabolic state could be useful for pharmacologic treatment and regeneration of the energetic status in ATP-depleted organs.
Publish Date	2015-01-27 15:33
Citation	Ferrigno A, Di Pasqua LG, Bianchi A, Richelmi P, Vairetti M. Metabolic shift in liver: Correlation between perfusion temperature and hypoxia inducible factor-1α. World J Gastroenterol 2015; 21(4): 1108-1116
URL	http://www.wjgnet.com/1007-9327/full/v21/i4/1108.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i4.1108

Full Article (PDF)	WJG-21-1108.pdf
Full Article (Word)	WJG-21-1108.doc
Manuscript File	12069-Review.docx
Answering Reviewers	12069-Answering reviewers.pdf
Copyright License Agreement	12069-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	12069-Language certificate.pdf
Peer-review Report	12069-Peer review(s).pdf
Scientific Misconduct Check	12069-CrossCheck.jpg
Scientific Editor Work List	12069-Scientific editor work list.pdf