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Articles Published Processes
12/20/2014 9:24:00 PM | Browse: 1414 | Download: 1406
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Received |
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2014-06-24 20:12 |
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Peer-Review Started |
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2014-06-25 18:48 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-08-08 14:31 |
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Revised |
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2014-09-22 00:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-11-27 21:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-12-01 13:44 |
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Articles in Press |
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2014-12-01 14:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-12-11 16:14 |
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Publish the Manuscript Online |
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2014-12-20 19:42 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Genetic polymorphism in pathogenesis of irritable bowel syndrome
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cynthia KY Cheung and Justin CY Wu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Justin CY Wu, Professor, Institute of Digestive Disease, The Chinese University of Hong Kong, 9/F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong, China. justinwu@cuhk.edu.hk |
| Key Words |
Irritable bowel syndrome; Genetic polymorphism; Cytokines; Serotonin; Psychiatric distress; Endocannabinoids |
| Core Tip |
Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS. Although a number of IBS- related genes have been identified, the majority of the identified genes required further validation as each of them may only contribute to the pathophysiology in 1%-5% in patients with functional gastrointestinal disorders. |
| Publish Date |
2014-12-20 19:42 |
| Citation |
Cheung CKY, Wu JCY. Genetic polymorphism in pathogenesis of irritable bowel syndrome. World J Gastroenterol 2014; 20(47): 17693-17698 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i47/17693.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i47.17693 |
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