Publication Name	World Journal of Gastroenterology
Manuscript ID	12159
Country	China

Received	2014-06-24 20:12
Peer-Review Started	2014-06-25 18:48
To Make the First Decision	2014-08-06 17:22
Return for Revision	2014-08-08 14:31
Revised	2014-09-22 00:00
Second Decision	2014-11-27 21:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-01 13:44
Articles in Press	2014-12-01 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-11 16:14
Publish the Manuscript Online	2014-12-20 19:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Genetic polymorphism in pathogenesis of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Cynthia KY Cheung and Justin CY Wu
Funding Agency and Grant Number
Corresponding Author	Justin CY Wu, Professor, Institute of Digestive Disease, The Chinese University of Hong Kong, 9/F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong, China. justinwu@cuhk.edu.hk
Key Words	Irritable bowel syndrome; Genetic polymorphism; Cytokines; Serotonin; Psychiatric distress; Endocannabinoids
Core Tip	Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS. Although a number of IBS- related genes have been identified, the majority of the identified genes required further validation as each of them may only contribute to the pathophysiology in 1%-5% in patients with functional gastrointestinal disorders.
Publish Date	2014-12-20 19:42
Citation	Cheung CKY, Wu JCY. Genetic polymorphism in pathogenesis of irritable bowel syndrome. World J Gastroenterol 2014; 20(47): 17693-17698
URL	http://www.wjgnet.com/1007-9327/full/v20/i47/17693.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i47.17693

Full Article (PDF)	WJG-20-17693.pdf
Full Article (Word)	WJG-20-17693.doc
Manuscript File	12159-Review.docx
Answering Reviewers	12159-Answering reviewers.pdf
Copyright License Agreement	12159-Copyright assignment.pdf
Peer-review Report	12159-Peer review(s).pdf
Scientific Misconduct Check	12159-CrossCheck.jpg
Scientific Editor Work List	12159-Scientific editor work list.pdf