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12/20/2014 9:24:00 PM | Browse: 585 | Download: 389
Publication Name World Journal of Gastroenterology
Manuscript ID 12159
Country/Territory China
Received
2014-06-24 20:12
Peer-Review Started
2014-06-25 18:48
To Make the First Decision
2014-08-06 17:22
Return for Revision
2014-08-08 14:31
Revised
2014-09-22 00:00
Second Decision
2014-11-27 21:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-12-01 13:44
Articles in Press
2014-12-01 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-11 16:14
Publish the Manuscript Online
2014-12-20 19:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Genetic polymorphism in pathogenesis of irritable bowel syndrome
Manuscript Source Invited Manuscript
All Author List Cynthia KY Cheung and Justin CY Wu
Funding Agency and Grant Number
Corresponding Author Justin CY Wu, Professor, Institute of Digestive Disease, The Chinese University of Hong Kong, 9/F, Clinical Science Building, Prince of Wales Hospital, Shatin, Hong Kong, China. justinwu@cuhk.edu.hk
Key Words Irritable bowel syndrome; Genetic polymorphism; Cytokines; Serotonin; Psychiatric distress; Endocannabinoids
Core Tip Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS. Although a number of IBS- related genes have been identified, the majority of the identified genes required further validation as each of them may only contribute to the pathophysiology in 1%-5% in patients with functional gastrointestinal disorders.
Publish Date 2014-12-20 19:42
Citation Cheung CKY, Wu JCY. Genetic polymorphism in pathogenesis of irritable bowel syndrome. World J Gastroenterol 2014; 20(47): 17693-17698
Url http://www.wjgnet.com/1007-9327/full/v20/i47/17693.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i47.17693
Full Article (PDF) WJG-20-17693.pdf
Full Article (Word) WJG-20-17693.doc
Manuscript File 12159-Review.docx
Answering Reviewers 12159-Answering reviewers.pdf
Copyright License Agreement 12159-Copyright assignment.pdf
Peer-review Report 12159-Peer review(s).pdf
Scientific Misconduct Check 12159-CrossCheck.jpg
Scientific Editor Work List 12159-Scientific editor work list.pdf